| p16和Rb基因在人肝细胞癌中的表达 |
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| 引用本文： | 段小娴,罗丹.p16和Rb基因在人肝细胞癌中的表达[J].四川肿瘤防治,2001,14(2):75-76. |
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| 作者姓名： | 段小娴 罗丹 |
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| 作者单位： | 段小娴（广西肿瘤防治研究所,南宁,530021）
罗丹（广西肿瘤防治研究所,南宁,530021） |
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| 摘 要： | 目的：分析p16基因和视网膜母细胞瘤基因（Rb）在人肝癌细胞中表达的改变。方法：用免疫组织化学方法40例肝细胞癌和癌旁组织进行检测。结果：肝组织中的p16蛋白和Rb蛋白的异常表达分别为94．44％（34／36）和45．71％（16／35）。p16蛋白阴性或弱阳性而Rb呈强阳性者13例（13／34，38．23％），两者的表达呈负相关关系。p16和Rb蛋白均异常者15例（15／34，44．11％），表明Rb蛋白表达的调节除p16外，还有其他途径。二者的异常表达与肝癌的恶性程度无相关关系。结论：细胞调节因子p16和Rb基因的异常表达，均参与肝细胞癌的发生。以p16蛋白表达的改变为主。
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| 关 键 词： | 肝细胞癌 p16基因 Rb基因 表达 |
| 文章编号： | 1007-0281(2001)02-0075-02 |
| 修稿时间： | 2001年1月31日 |
The Expression of p16 and pRb in Hepatocellular Carcinoma |
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| DUAN Xiao xian LUO DanHospital of Guangxi Medical University,Nanning.The Expression of p16 and pRb in Hepatocellular Carcinoma[J].Sichuan Journal of Cancer Control,2001,14(2):75-76. |
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| Authors: | DUAN Xiao xian LUO DanHospital of Guangxi Medical University Nanning |
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| Institution: | DUAN Xiao xian LUO DanHospital of Guangxi Medical University,Nanning 530021 |
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| Abstract: | Objective:To investigate the expression of p16 gene and retinoblastoma protein(pRb)in human hepatocellular carcinoma(HCC).Methods:40 cases of HCC and their adjacent tissues were examined by immunohistochemistry method.Results:The expression of p16 and pRb in liver showed abnormal,i,e,94.44%(34/36)and 45.71%(16/35),respectively.The expression of p16 and pRb showed negative correlation.The abnormal expression of p16 and Rb had no relation with degree of malignancy.Conclusion:Our rcsults suggested that abnormal expression of p16 and pRb maybe involved in the occurrence of HCC and the change of p16 is prominent. |
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| Keywords: | Hepatocelluar carcinoma p16 pRb |
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