The 5-HT1A agonist 8-OH-DPAT attenuates the satiating action of cholecystokinin. |
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| Authors: | B Poeschla J Gibbs K J Simansky G P Smith |
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| Affiliation: | Department of Psychiatry, Cornell University Medical College, White Plains, NY. |
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| Abstract: | To investigate the dependence of the satiating action of cholecystokinin (CCK) on serotonergic action at central 5-HT receptors, we examined the effect of systemic pretreatment with 8-OH-DPAT (a 5-HT1A agonist that decreases central 5-HT synthesis and release via an action at somatodendritic autoreceptors in the brainstem raphe) on the suppression of food intake induced by systemic administration of cholecystokinin octapeptide (CKK-8). 8-OH-DPAT significantly attenuated the satiating action of CKK-8. This result is consistent with the hypothesis that peripherally acting CCK recruits central serotonergic processes to elicit normal satiety. |
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