巨细胞病毒感染与冠心病关系的临床研究

目的　探讨人类巨细胞病毒 (HCMV)感染与冠心病的关系。方法　采用间接ELISA法检测其外周血巨细胞病毒抗体 ,同时应用免疫透射比浊法测定其C反应蛋白的水平。结果　冠心病组 6 0例 ,外周血巨细胞病毒抗体IgG阳性 2 6例 (4 3 3% ) ,健康对照组 6 0例中阳性 10例 (16 6 % ) ,两组比较差异有显著意义 (P <0 0 5 )。HCMV抗体阳性者 2 6例同时检测外周血CRP水平大于正常者 2 0例 (76 9% ) ,正常对照组2 6例CRP水平大于正常者 3例 (11 5 % ) ,两组比较差异有显著意义 (P <0 0 1)。结论　巨细胞病毒感染与冠心病之间关系密切。

Clinical study of the relationship between human cytomegalovirus infection and coronary heart disease

Objective To investigate the relationship between human cytomegalovirus(CMV) infection and coronary heart disease(CHD).Methods The antibodies of human CMV were detected by indirect ELISA technique and the level of C reactive protein(CRP) by immunotubidimetric.Results In 60 patients with coronary heart disease 26 cases(43.3%) were considered as positive for CMV infection.In comparasion,positive band was detected in only 16.6%(10/60 cases) in healthy objectives.This difference of CMV infection between two groups was statistically significant(P<0.05).At the same time we assayed the CRP level of the 26 cases whose antibodies of human CMV were positive and 26 cases of healthy control.There were 20 cases(76.9%) whose CRP level were higher than that in the 26 cases whose CMV antibodies were positive.There were 3 cases(11.5%) whose CRP level were higher in 26 healthy controls.This difference between two groups was statistically significant(P<0.01).Conclusion CMV infection is related to coronary heart disease.