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Synthesis and studies of novel 2-(4-cyano-3-trifluoromethylphenyl amino)-4-(quinoline-4-yloxy)-6-(piperazinyl/piperidinyl)-s-triazines as potential antimicrobial, antimycobacterial and anticancer agents |
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| Authors: | Patel Rahul V Kumari Premlata Rajani Dhanji P Chikhalia Kishor H |
| Affiliation: | a Department of Applied Chemistry, S.V. National Institute of Technology, Surat 395 007, Gujarat, India b Microcare Laboratory, Surat 395 001, Gujarat, India c Department of Chemistry, School of Science, Gujarat University, Ahmedabad 380 009, Gujarat, India |
| Abstract: | A series of novel s-triazine analogs were synthesized and characterized by IR, 1H NMR, 13C NMR, 19F NMR spectroscopy and elemental analysis. Preliminary screening of target compounds against eight bacteria (Staphylococcus aureus, Bacillus cereus, Escherichia coli, Pseudomonas aeruginosa, Klebsiella pneumoniae, Salmonella typhi, Proteus vulgaris, Shigella flexneria), four fungi (Aspergillus niger, Aspergillus fumigatus, Aspergillus clavatus, Candida albicans) and Mycobacterium tuberculosis H37Rv indicated that 5d, 5h, 5n, 5p, 5q, 5r, 5s, 5t and 5u were the most active compounds among twenty one studied. Thus, they were further subjected to in vitro biological evaluation against human prostate cancer cell line (DU-145) and the results indicate that two compounds 5n and 5s were markedly active. |
| Keywords: | 2,4,6-Trichloro-1,3,5-triazine 4-Hydroxyquinoline Piperazine Antimicrobial activity Antimycobacterial activity Anticancer activity |
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