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| 酒精联合高脂饮食对大鼠胰岛素敏感性的影响及其分子机制 | |
| 引用本文： | 孙璇,赵立娜,徐肇明,彭晓琳,郝丽萍,孙秀发.酒精联合高脂饮食对大鼠胰岛素敏感性的影响及其分子机制[J].中华内分泌代谢杂志,2009,25(6). |
| 作者姓名： | 孙璇 赵立娜 徐肇明 彭晓琳 郝丽萍 孙秀发 |
| 作者单位： | 1. 深圳市人民医院血液内科 2. 华中科技大学同济医学院公共卫生学院营养与食品卫生学系,武汉,430030 3. 深圳市人发医院血液内科 |
| 摘 要： | 研究酒精和高脂对大鼠胰岛素敏感性的影响.测大鼠血糖、血胰岛素和葡萄糖转运蛋白4(GLUT-4)mRNA及蛋白表达水平.结果 示各剂量组血糖、胰岛素抵抗指数升高(均P<0.05),GLUT-4mRNA及蛋白表达显著降低(均P<0.05). |
| 关 键 词： | 稳态模型评估的胰岛素抵抗指数 葡萄糖转运子4 胰岛素抵抗 |
Combined effects of alcohol and high-fat diet on insulin sensitivity in rats and its molecular mechanisms |
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| Abstract: | To investigate the combined effect of alcohol and hish-fat on insulin sensitivity.Fasting plasma ghucose,plasma insulin of rats were measured,and glucose transportor-4(GLUT4)mRNA and protein were analysed.Compared with the control group,fasting plasma glucose and homeostasis model assessment for insulin resistance(HOMA-IR) were increased in other groups,GLUT-4 mRNA and protein expression levels were decreased(all P<0.05). |
| Keywords: | Homeostasis model assessment for insulin resistance index Glucose transportor-4 Insulin resistance |
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