Comparative efficacies of different antibiotic treatments to eradicate nontypeable <Emphasis Type="Italic">Haemophilus influenzae</Emphasis>infection |
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| Authors: | Yukie Sekiya Masahiro Eguchi Masahiko Nakamura Kimiko Ubukata Satoshi Omura Hidenori Matsui |
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| Institution: | (1) Center for Basic Research, The Kitasato Institute, Minato-ku Tokyo, 108-8642, Japan;(2) Kitasato Institute for Life Sciences and Graduate School of Infection Control Sciences, 5-9-1 Shirokane, Minato-ku Tokyo, 108-8641, Japan;(3) Center for Clinical Pharmacy and Clinical Sciences, School of Pharmaceutical Sciences, 5-9-1 Shirokane, Minato-ku Tokyo, 108-8641, Japan |
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| Abstract: | Background Nonencapsulated and nontypeable Haemophilus influenzae (NTHi) is a major cause of human respiratory tract infections. Some strains of NTHi can cause invasive diseases such as septicemia
and meningitis, even if H. influenzae is not generally considered to be an intracellular pathogen. There have been very few reports about the therapeutic efficacy
of antibiotics against respiratory tract infection caused by NTHi in mice because it is difficult for H. influenzae to infect mice. Therefore, we evaluated the efficacy of antibiotics against NTHi in both a cell culture model and a mouse
model of infection. |
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