浙江省602例选择性冠状动脉造影患者血脂水平分析

目的研究经选择性冠状动脉造影证实的冠状动脉粥样硬化性心脏病(冠心病)与非冠心病患者血脂水平的差异。方法测定602例住院行选择性冠状动脉造影患者血清总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)和非高密度脂蛋白胆固醇(nonHDL-C)水平,并根据冠脉造影结果进行比较分析。结果冠心病组血清TC、LDL-C、nonHDL-C稍高于对照组(4．70 mmol／L±1．22 mmol／L vs．4．49 mmol／L±0．96 mmol／L、2．63 mmol／L±1．00 mmol／L vs．2．44 mmol／L±0．77 mmol／L、3.45 mmol／L±1．14 mmol／L vs．3．22 mmol／L±0.92 mmol／L),差异有统计学意义(P<0．05,P<0．01);组间不同水平血脂的构成比除HDL-C、nonHDL-C外差异无统计学意义(P>0．05)。结论高脂血症并非浙江省冠状动脉粥样硬化患者的固有特征,冠心病与非冠心病人群血脂水平存在较大的重叠。

Investigation on levels of serum lipids among 602 patients who had undergone coronary angiography in Zhejiang province

OBJECTIVE: To observe the difference of serum lipid levels between patients with coronary heart disease(CHD) and those without,in Zhejiang province. METHODS: According to coronary angiogram, 602 patients were divided into two groups as group 1 (vessel stenosis > or =50% luminal diameter narrowing of at least one major coronary artery), group 2 (no vessel stenosis or vessel stenosis <50% luminal diameter narrowing ). Their serum triglyceride (TG), total cholesterol (TC), lower density lipoprotein cholesterol (LDL-C), higher density lipoprotein cholesterol (HDL-C) and non-high density lipoprotein cholesterol (non-HDL-C) were measured and analysed. RESULTS: Serum lipid levels of the two groups were all close to the proper scopes of Principles for the prevention of dyslipidemia recommended by dyslipemia group of the editorial board of Chinese Journal of Cardiology. Data also showed that levels of serum TC, LDL-C and non-HDL-C in group 1 were alightly higher than those in group 2 (4.70 mmol/L +/- 1.22 mmol/L vs. 4.49 mmol/L +/- 0.96 mmol/L, 2.63 mmol/L +/- 1.00 mmol/L vs. 2.44 mmol/L+/- 0.77 mmol/L, 3.45 mmol/L+/- 1.14 mmol/L vs. 3.22 mmol/L+/- 0.92 mmol/L, P < 0.05, P< 0.01, respectively). CONCLUSION: Hyperlipidemia was not a inherent characteristic for CHD patients in Zhejiang province.