肺癌患者血清P53抗体的检测及其临床意义

目的探讨肺癌患者测定血清p53抗体的临床意义.方法采用ELISA法检测120例肺癌患者术前血清p53抗体,并以30例肺部良性疾病患者和120例正常健康人作对照.结果(1)肺癌患者血清p53抗体水平和阳性率均明显高于肺部良性疾病患者和正常人(P<0.05)而正常人与肺部良性疾病患者间无显著差异(P>0.05).(2)肺癌患者血清p53抗体水平和阳性率均与肺癌细胞分化程度和病期有密切关系(P<0.01或P<0.05).结论检测血清p53抗体有助于肺部良恶性疾病的诊断;术前测定有助于判断肺癌进展和分期.

Clinical Significance in Detecting Serum p53 Antibodies in Patients with Lung Cancers

Objective:To explore the clinical significance in detect ing serum p53 antbodies in patients with lung cancer.methods:One hundred and twenty patients with lung cancer were tested for p53 antibodi es by enzyme linke d immunosorbent assay(ELISA).Moreover,30 patient with benign pulmonary disease a nd 120 healthy individuals were recruited as controls.resuits:(1) The level and positive rate of serum p53 antbodies in patients with lung cancer were significantly higher than those in patients with benign pulmonary diseases and normal individuals( P <0 05),but there was no significant difference between patients with benign pulmonary diseases and normal individuals( P >0 0 5).(2)The level and positive rate of pre-operative serum p53 antibodies in patients with lung cancer were closely related to cell differentiation and stage of lung cancer( P <0 01 or P <0 05).Conclusion:Detection of serun p53 antbodies is helpful in the diagnosis of benign or malignant pulmonary diseases,an d estimation of the devlepment or stage,of lung cancers.