复方糖尿1号、2号胶囊临床应用110例疗效观察

目的观察复方糖尿1号、2号降血糖药物的疗效与安全。复方糖尿1号、2号胶囊，是一组治疗糖尿病的专用药物（批准文号：湘药制字7220060119及Z20060110；发明专利号ZL97013536．9）。临床应用10年来，深受广大糖尿病友的喜爱。复方中除含人参、三七、山茱萸、肉桂等中药成份外，还含有少量的格列本脲与盐酸二甲双胍。那么，它与同品种、同剂量的西药相比较，是否有优胜之处？方法针对这一问题，把110例2型糖尿患者分为复方组与纯西药组进行临床观察比较；将110例2型糖尿病患者分为复方组与纯西药组，分别测量其：空腹血糖（FPG）、餐后2h血糖（PG2h）、餐后1hC肽（CP-1h）、餐后1h胰岛素（Ins-1h）、尿素氮（BUN）、谷丙转氨酶（SGPT），并记录两组患者的气虚症状（如：乏力、神疲）；消化道反应等。结果在降餐后血糖方面，复方组与对照组比较，P〈0．01，且消化道症状发生率仅为10％，气虚症状好转率为69％；且在治疗剂量下，所观察的病例未见到对肝、肾功能的不良影响及低血糖事件。结论复方组在降血糖方面，其稳定性好、离散性小，效果更佳；在改善气虚症状、减少消化道反应方面，也均优于纯西药组，是一组安全有效的降血糖药物。

Investigation for the effevt 110 cases by clinical application of compound formula diabetes capsules No 1 & No 2

Objective To investigate the effect and safety of hypoglycemic agents of the compound for-mula diabetes No. 1&No. 2. The compound formula diabetes capsules No. 1 &No. 2 are a special group of medi-cine for treating diabetes. (Apporval No: Xiang yaozhizi Z 20060119&Z 20060110, Patent No: ZL97013536. 9). For 10 years' clinical application, they are popular among the numerous diabetes. The compound formula not on-ly contains the chinese medicinal compositions, such as: ginseng, notoginseng, cornus, cinnamon, also involves a few of glinben clanide and mdfformin hydro-chloride. Then, has it an advantage by comparing with the same kind and same dose of the western medicine. Methods To this problem, we took clinical investigation by divding 110 cases diabetes Ⅱ into two groups(the compound formula group and the pure western mesicene group). Separately examed: FPG, PG2 H, CP-1 h, Ins-1 h, BUN, SGPT and wrote down each group' s vacuity symptoms (such as :lack of strength,fatigued spirit)and the reaction of oligestive system. Results In the aspect for hypoglycine after med, the compound formula group for 63.1143, P < 0. 001 by comparing with another group, and the happening rate of digestive symptoms only 10%, the vacuity symptoms getting better at 69% ,under the amount of dosage, no abnormal effection on liver and kidney, and no hypoglycemia. Conclusion The compound formula group has ga good stability, a little dissipation and better result in hypoglyeine; and is also better than the pure western medicing group in improving vacuity symptom and in digestive system. The compound formula diabetes capsules No. 1 &No. 2 are a safe and effective group of medicine for treating diabetes.