| 盐酸氨溴索注射液在果糖注射液中的配伍稳定性研究 |
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| 引用本文： | 叶华a,熊建华b,李笑慧b. 盐酸氨溴索注射液在果糖注射液中的配伍稳定性研究[J]. 中国现代应用药学, 2010, 27(5): 468-470 |
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| 作者姓名： | 叶华a 熊建华b 李笑慧b |
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| 作者单位： | 温州医学院温州市第三临床学院;温州市第三人民医院神经内科;温州市第三人民医院药剂科; |
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| 摘 要： | 目的考察25℃和37℃下盐酸氨溴索注射液在果糖注射液中配伍的稳定性。方法采用高效液相色谱法测定氨溴索与果糖注射液配伍一定时间后的含量,同时观察外观变化并测定其pH值。结果药物在25℃和37℃果糖注射液中配伍后,0-8 h内其外观、pH值及含量均无明显变化。结论两药液配伍后在8 h内稳定,可配伍使用。
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| 关 键 词： | 氨溴索 果糖注射液 稳定性 高效液相色谱法 配伍 |
Investigation of the Compatible Stability of Ambroxol Hydrochloride Injection in 5% Fructose Injection |
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| YE Hu,XIONG Jianhu,LI Xiaohui. Investigation of the Compatible Stability of Ambroxol Hydrochloride Injection in 5% Fructose Injection[J]. The Chinese Journal of Modern Applied Pharmacy, 2010, 27(5): 468-470 |
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| Authors: | YE Hu XIONG Jianhu LI Xiaohui |
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| Affiliation: | Wenzhou 3rd Clinical College of Wenzhou Medical College, The Third People's Hospital of Wenzhou, Wenzhou 325000, China |
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| Abstract: | OBJECTIVE To study the compatible stability of ambroxol hydrochloride in 5% fructose injection at 25 ℃and 37 ℃ for 8 hours respectively.METHODS Ambroxol hydrochloride in fructose injection was assayed with HPLC at different time points after being mixed,and the appearance and pH values of the mixed solutions were observed as well.RESULTS The content,appearance and pH values of ambroxol hydrochloride mixed with fructose injection were stable at 25 ℃ and 37 ℃ within 8 hours.CONCLUSION Ambroxol hydrochloride can be mixed with fructose injection for clinical use. |
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| Keywords: | ambroxol fructose injection stability HPLC compatibility |
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