Le tissu adipeux : un donneur de cellules souches ? |
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Authors: | Anne Bouloumié ,Sandra De Barros,Marie Maumus,Jean Galitzky,Coralie Sengenes |
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Affiliation: | Inserm, Équipe Avenir, INSERM U858, Institut de médecine moléculaire de Rangueil, Toulouse ; Université Paul Sabatier, Institut Louis Bugnard IFR31, Toulouse |
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Abstract: | Several laboratories have shown that the cells from the stroma-vascular fraction of the human adipose tissue express, depending on cell culture conditions, biochemical markers of multiple cell lineages including adipogenic, osteogenic, chondrogenic, myogenic, endothelial, neuronal and epithelial cell lineage. Furthermore, various in vivo approaches revealed the ability of the cells derived from the stroma-vacsular fraction of adipose tissue to repair ischemic or damaged tissues. Altogether these data strongly suggest that the stroma-vascular fraction of the human adipose tissue contains cells that exhibit properties like stem/progenitor cells. However, the exact nature of the cells, their potentiality to lead to differentiated cells in vivo as well as the mechanisms involved in their repair capability remain to be characterized to consider their use in regenerative and reparative medicine. |
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Keywords: | Cellule progé nitrice Pré adipocyte Cellules endothé liales Ré paration Ré gé né ration |
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