Induction of monocyte chemotaxis in devascularized rabbit bone |
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| Authors: | M R Sarkar B A Rahn U Pfister H U Keller S M Perren |
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| Institution: | (1) Abteilung für Unfallchirurgie, Städtisches Klinikum, Karlsruhe, Germany;(2) Labor für experimentelle Chirurgie, Schweizerisches Forschungsinstitut, Davos, Switzerland;(3) Institut für Pathologie, Universität Bern, Bern, Switzerland;(4) Chirurgische Klinik, Städtisches Klinikum, Moltkestrasse 14, D-7500 Karlsruhe 1, FRG |
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| Abstract: | Summary Temporary impairment of blood supply has been suggested to cause bone remodeling. The degradation of cells and matrix and the attraction of resorbing cells were examined in this study. Bone specimens of rabbits were stored in vitro for 2–20 days. At the end of this aging process the probes were tested for their chemotactic activity toward autologous leukocytes in a diffusion chamber. Both supernatant from the aged bone specimens and ground bone particles exhibited significant chemotactic activity that was specifically attracting monocytes. It is suggested that soluble bone matrix proteins or degeneration products liberated during ischemic damage to cortical bone initiate the resorptive process.This work was supported by the Swiss National Science Foundation, grant no. 3.857.0.83, and by the Studienstiftung des deutschen Volkes |
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