水蛭防治初发期急性肾功能衰竭的实验研究

为了观察水蛭对初发期急性肾小管坏死(ATN)的防治作用,用禁水16h的成年雄性SD大鼠肌肉注射甘油引起ATN,在初发期给以不同药液,观察到水蛭组3、24、48h Ber升高值,24、48h BUN升高值均明显低于自来水组和单纯禁水组,而与纠正对照异搏停组相似;3、24h肾脏组织形态学损伤水蛭组亦较自来水组和单纯禁水组明显减轻。结果表明,水蛭有防治初发期ARF的作用。

Preventive and Therapeutic Effects of Hirudo on Incipient Acute Tubular Necrosis in Rats

Male Sprague-Dawley rats, weighing 180-250 g and depleted with water for 16h, were injectedwith glycerol (im) to induce acute tubular necrosis, and then divided into groups given blood-activating and stasis-removing drug, Hirudo solution (GH). tap water (GW), verapamil (GV) and none(GSDW) in incipient stage separately. It was observed that levels of BUN increased at 24th and 48thh after administration of glycerol and levels of Bcr increased at 3rd, 24th and 48th h after injectingglycerol in GH were significantly lower than those increased in GW and GSDW (P<0.05--P<0.001), but roughly similar to those in GV (P<0.05--P<0.5).Renal histopathological damage underlight microscope and electron-microscope in GH at 3rd and 24th h after administration of glycerolwere also less severe than those in GW and GSDW. The results suggested that Hirudo could exerta preventive and therapeutic effects on incipient acute tubular necrosis induced by glycerol in rats.