| 川芎嗪和阿魏酸单用和合用对血管平滑肌、血液粘度、急性毒性的影响和比较 |
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| 引用本文： | 徐军,李仪奎,梁子钧. 川芎嗪和阿魏酸单用和合用对血管平滑肌、血液粘度、急性毒性的影响和比较[J]. 中国中药杂志, 1992, 17(11): 680-682 |
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| 作者姓名： | 徐军 李仪奎 梁子钧 |
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| 作者单位： | 上海中医学院,200032 |
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| 摘 要： | 运用q值计算方法评价川芎嗪和阿魏酸的合并效应。实验发现两药合用对兔和大鼠离体主动脉痉挛性收缩的缓解作用、增加豚鼠心脏灌流量及降低大鼠全血粘度等作用与单用该两药相比呈协同;而对小鼠急性毒性,合用时毒性为拮抗。
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| 关 键 词： | 川芎嗪 阿魏酸 主动脉 心脏 血液粘度 |
Effects of Tetramethylpyrazine and Ferulie Acid Alone or Combined on Vascular Smooth Muscle, Blood Viscosity and Toxicity |
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| Abstract: | The experiments showed that both tetramethylpyrazine and ferulic acid relaxed the norepinephrine-induced spasmodic contraction of rabbit and rat aorta strips, increased the coronary flow of isolated guinea pig hearts and reduced the whole blood viscosity in rats. Evaluated with Burgi's equation, the combined effect of these 2 drugs was obviously potentiated, but the combined acute toxicity in mice was greatly reduced. |
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| Keywords: | tetramethylpyrazine ferulic acid aorta heart blood viscosity |
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