| 冠状动脉粥样硬化不稳定斑块中肥大细胞分布与血管新生相关性研究 |
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| 引用本文： | 郭素芬,张瑞云,成永霞,李志强.冠状动脉粥样硬化不稳定斑块中肥大细胞分布与血管新生相关性研究[J].牡丹江医学院学报,2009,30(2):1-3. |
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| 作者姓名： | 郭素芬 张瑞云 成永霞 李志强 |
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| 作者单位： | 1. 牡丹江医学院病理教研室,黑龙江,牡丹江,157011
2. 牡丹江医学院附属红旗医院儿科,黑龙江,牡丹江,157011 |
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| 基金项目： | 牡丹江医学院重点项目 |
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| 摘 要： | 目的：探讨冠状动脉粥样硬化斑块不同区域肥大细胞的分布及与新生血管的关系。方法：将经苏木素一伊红染色筛选出的属于中晚期的动脉粥样硬化病变（脂质核心面积大于斑块面积的40％）的组织块和10例尸检正常冠状动脉标本进行抗肥大细胞类胰蛋白酶和CD31单克隆抗体免疫组化染色。结果：在正常内膜、斑块的纤维帽区、核心区、肩区肥大细胞密度（细胞如视野）和新生微血管密度（微血管杉视野）分别为1．2±1．7、2．6±2．1、3．1±2．4、7．2±3．9和0、2．8±1．6、3．6±1．8、8．3±2．6，斑块肩区肥大细胞密度（MCD）和新生微血管密度（MVD）明显高于其它部位（P〈0．05或P〈0．01）且二者存在明显的正相关（r=0．545；P〈0．05）。结论：冠状动脉粥样硬化斑块中肥大细胞的分布与新生微血管密度具有相关性且可能影响斑块的稳定性。
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| 关 键 词： | 冠状动脉粥样硬化 肥大细胞 血管新生 斑块 |
STUDY OF THE CORRELATION BETWEEN DISTRIBUTION OF MAST CELLS AND ANGIOGENESIS IN ATHEROSCLEROTIC LESIONS OF HUMAN CORONARY ARTERIES |
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| Guo Sufen et al.STUDY OF THE CORRELATION BETWEEN DISTRIBUTION OF MAST CELLS AND ANGIOGENESIS IN ATHEROSCLEROTIC LESIONS OF HUMAN CORONARY ARTERIES[J].Journal of Mudanjiang Medical College,2009,30(2):1-3. |
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| Authors: | Guo Sufen |
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| Institution: | Guo Sufen et al(Mudanjiang Medical universityMudanjiangHeilongjiang157011) |
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| Abstract: | Objective:To study the distribution of mast cells in atherosclerotic lesions of human coronary arteries,and to investigate the relationship between mast cell density(MCD) and microvessel density(MVD).Methods:42 samples with coronary atherosclerosis and 10 autopsies of normal coronary arteries specimens were obtained.Plaque morphology was evaluated by using hematoxylin and eosin stained slides.Then,tissue blocks with large extracellular lipid core(more than 40% of the Plaque area)were needed and all were sta... |
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| Keywords: | coronary atherosclerosis mast cells angiogenesis plaque |
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