| 表没食子儿茶素没食子酸酯对胃癌肿瘤血管生成的影响 |
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| 引用本文： | 吴宏菊,胡跃云,李文会,陈宏,肖玉平,辛彦. 表没食子儿茶素没食子酸酯对胃癌肿瘤血管生成的影响[J]. 中国医科大学学报, 2011, 40(6): 494-496 |
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| 作者姓名： | 吴宏菊 胡跃云 李文会 陈宏 肖玉平 辛彦 |
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| 作者单位： | 中国医科大学附属第一医院肿瘤研究所第四研究室,普通外科研究所肿瘤病理研究室,沈阳110001 |
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| 基金项目： | 国家自然科学基金资助项目(30973503、81071650和81050007); 辽宁省高校攀登学者支持计划(2009-2011); 高等学校博士学科点专项科研基金(20092104110008); 沈阳市科学技术计划项目(F10-149-9-45) |
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| 摘 要： | 目的 探讨表没食子儿茶素没食子酸酯(EGCG)对胃癌肿瘤血管生成的影响及其机制.方法 建立人胃腺癌BGC-823细胞裸鼠移植瘤模型,观察肿瘤生长及毒副作用.免疫组化染色测定CD31和血管内皮生长因子(VEGF)表达.结果 与对照组比较,EGCG明显抑制了肿瘤的生长,EGCG组的平均瘤重明显低于对照组(P<0.05),抑...
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| 关 键 词： | 血管生成 表没食子儿茶素没食子酸酯 胃肿瘤 |
Antiangiogenic Effect of(-)-Epigallocatechin-3-Gallate on Gastric Cancer |
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| WU Hong-ju , HU Yue-yun , LI Wen-hui , CHEN Hong , XIAO Yu-ping , XIN Yan. Antiangiogenic Effect of(-)-Epigallocatechin-3-Gallate on Gastric Cancer[J]. Journal of China Medical University, 2011, 40(6): 494-496 |
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| Authors: | WU Hong-ju HU Yue-yun LI Wen-hui CHEN Hong XIAO Yu-ping XIN Yan |
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| Affiliation: | WU Hong-ju,HU Yue-yun,LI Wen-hui,CHEN Hong,XIAO Yu-ping,XIN Yan(The Fourth Laboratory of Cancer Institute,Department of Tumor Pathology of General Surgery Institute,The First Hospital,China Medical University,Shenyang 110001,China) |
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| Abstract: | Objective To investigate the antiangiogenic effect of(-)-epigallocatechin-3-gallate(EGCG) on gastric cancer and to explore its mechanism.Methods BGC-823 human gastric cancer xenograft model was constructed.Tumor growth and side effects were closely monitored.Expression of VEGF and CD31 were observed by immunohistochemistry.Results Compared with the control group,EGCG significantly inhibited BGC-823 tumor growth in the absence of toxicity;the average tumor weight was markedly lower in the EGCG group(P <0.05)... |
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| Keywords: | angiogenesis (-)-epigallocatechin-3-gallate stomach neoplasms |
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