不同剂量血小板输注效果的Meta分析

目的系统评价患者输注高剂量血小板和低剂量血小板的效果。方法计算机检索PubMed、Embase、Cochrane图书馆和中国生物医学文献数据库，检索年限从建库至2011年12月。纳入高剂量与低剂量血小板输注的随机对照试验（RCT）。采用RevMan5．0软件进行Meta分析。结果研究共纳入6个RCT。输注高剂量血小板的患者再次输注血小板的时间间隔长于输注低剂量血小板的患者MD=1．05，95％CI（O．89，1．20），P〈0．001]，输注后血小板计数增加值高于输注低剂量血小板的患者MD=17．38，95％CI（14．58，20．18），P〈0．001]，但出血频率两组间差异无统计学意义RR-0．77，95％CI（0．48，1．23），P=0．273。结论与输注低剂量血小板相比，输注高剂量血小板可以延长患者再次输注血小板的时间间隔，提高患者输注后的血小板计数，但对出血频率无显著影响。

Different Dose of Platelet Transfusion Effect: A Meta-Analysis

Objective To assess the comparative effect of high dose platelet transfusion and low dose platelet trans- fusion. Methods Randomized controlled trials （RCTs） comparing high dose and low dose platelet transfusion were searched and identified from PubMed, EMBASE, Cochrane Library and CBM database. The meta-analysis was conducted by Cochrane Collaboration＇s RevMan 5.0 software. Results Six studies were selected to meta-analysis. The data showed that compared to low dose platelet transfusion, high dose platelet transfusion prolonged transfusion intervalEMD： 1.05, 95%CI（0. 89,1. 20） ,P〈0. 001, increased post-transfusion platelet count incrementEMD： 17.38,95%CI（14.58,20.18）, P 〈 0. 0011, but there was no difference of bleeding event occurring ERR = 0.77,95 %CI （0.48,1.23）,P = 0.27. Conclu- sion The current evidence suggests that high dose platelet transfusion can prolong transfusion interval and increase post- transfusion platelet count increment, but do not influence bleeding.