乳腺癌绝经前后c-erbB-2、ER、PR的表达及与预后的相关性

 目的 探讨乳腺癌绝经前后c-erbB-2、ER、PR受体的表达差异及其与预后的相关性。 方法 回顾性分析432例乳腺癌的病理学资料，其中195例患者随访5年，c-erbB-2、ER、PR的表达采用免疫组化法检测。 结果 （1）绝经前组，c-erbB-2阳性患者的ER阳性率显著低于c-erbB-2阴性患者（P=0.003）；绝经后组，c-erbB-2阳性患者的ER、PR阳性率均显著低于c-erbB-2阴性患者（P＜0.001，P=0.005）。（2）多因素分析显示，绝经前组的独立预后因素为淋巴结转移、c-erbB-2，绝经后组的独立预后因素为淋巴结转移、c-erbB-2和ER。 结论 绝经前与绝经后乳腺癌c-erbB-2、ER、PR受体表达的临床意义有所不同。

Expressions of c-erbB-2,ER,PR and Their Prognostic Correlation in Premenopausal and Postmenopausai Patients with Breast Cancer

Objective To investigate the expression of c-erbB-2, ER, PR and their prognostic relationship premenopausal and postmenopausal patients with breast cancer. Methods The pathological data of 432 patients with primary breast cancer were analyzed retrospectively. One hundred and ninety five patents were followed up for 5 years. The expression of c-erbB-2, estrogen receptor(ER) and progesterone receptor(PR) in cancer specimens of 432 patients were detected by immunohistochemistry in. Results (1) In premenopausal patients, the positive rate of ER expression in patients with positive expression of c-erbB-2 was significantly lower than that in patients with negative expression of c-erbB-2(P=0.003). In postmenopausal patients, the positive rate of ER and PR expression in patients with positive expression of c erbB 2 were significantly lower than those in patients with negative expression of c-erbB-2(P＜0.001,P=0.005).(2)The Cox multivariate analysis showed that c-erbB-2 expression and lymph node metastasis were independent prognostic factors in premenopausal patients, and that c-erbB-2 expression, lymph node metastasis and ER expression were independent prognostic factors in postmenopausal patients. Conclusion The clinical implications of c-erbB-2, ER and PR are different between premenopausal and postmenopausal patients with breast cancer.