| 超高效液相色谱法在中药分析领域中的应用现状及展望 |
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| 引用本文： | 谭鹏,李春雨,章从恩,张定堃,张海珠. 超高效液相色谱法在中药分析领域中的应用现状及展望[J]. 中草药, 2018, 49(24): 5938-5945 |
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| 作者姓名： | 谭鹏 李春雨 章从恩 张定堃 张海珠 |
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| 作者单位： | 成都市食品药品检验研究院, 四川 成都 610045;成都中医药大学药学院, 四川 成都 611137,国家癌症中心 中国医学科学院/北京协和医学院肿瘤医院, 北京 100021,首都医科大学附属北京友谊医院, 北京 100050,成都中医药大学药学院, 四川 成都 611137,大理大学药学与化学学院, 云南 大理 671000 |
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| 基金项目： | 国家自然科学基金资助项目（81630100）；国家中药标准化项目（ZYBZH-Y-BJ-07）；国家中药标准化项目（ZYBZH-C-HUN-21）；成都市科技局项目（2016-HM01-00312-SF）；成都市科技局项目（2018-YF05-01277-SN） |
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| 摘 要： | 中药具有化学成分复杂、性质差异大、分离困难等特点,药学工作者尝试运用各种分析方法来解析中药中的成分。随着液相色谱技术的发展,在中药分析领域的应用逐渐增多,也进一步促进了中药的深入研究。对超高效液相色谱的发展历程进行了梳理,并总结了其在中药分析领域中的应用现状,展望了超高效液相色谱未来的发展方向,为促进超高效液相色谱法在中药分析领域中更合理、更广泛的普及应用提供参考。
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| 关 键 词： | 超高效液相色谱法 中药 复杂成分 成分分析 指纹图谱 |
| 收稿时间： | 2018-08-19 |
Application status and prospect of ultra-performance liquid chromatography in analysis field of Chinese materia medica |
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| TAN Peng,LI Chun-yu,ZHANG Cong-en,ZHANG Ding-kun and ZHANG Hai-zhu. Application status and prospect of ultra-performance liquid chromatography in analysis field of Chinese materia medica[J]. Chinese Traditional and Herbal Drugs, 2018, 49(24): 5938-5945 |
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| Authors: | TAN Peng LI Chun-yu ZHANG Cong-en ZHANG Ding-kun ZHANG Hai-zhu |
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| Affiliation: | Chengdu Institute for Food and Drug Control, Chengdu 610045, China;College of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China,National Cancer Center, Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China,Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China,College of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China and Department of Pharmacy and Chemistry, Dali University, Dali 671000, China |
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| Abstract: | Chinese materia medica (CMM) have many unique characteristics, such as complex chemical compositions, large differences in properties, and difficulty in separation. Pharmacists try to use various analytical methods to analyze the chemical compositions in CMM. With the development of liquid chromatography technology, the ultra-high performance liquid chromatography (UPLC) has been applied in the analysis field of CMM, and further promoted the in-depth study of CMM. This paper summarizes the development history of HPLC and UPLC, describes its current application in the analysis field of CMM, and provides an outlook of the future development of UPLC. The purpose of this paper is to promote the more reasonable and wider application of UPLC in the field of CMM analysis. |
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| Keywords: | ultra-high performance liquid chromatography Chinese materia medica complex composition composition analysis fingerprint |
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