| 糖尿病视网膜病变微血管神经病变发病机制的研究进展 |
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| 引用本文： | 陈丹丹,帅天姣,李娟,孙小航,王瑞英,朴天华.糖尿病视网膜病变微血管神经病变发病机制的研究进展[J].国际眼科杂志,2018,18(5):844-846. |
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| 作者姓名： | 陈丹丹 帅天姣 李娟 孙小航 王瑞英 朴天华 |
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| 作者单位： | 中国黑龙江省牡丹江市,牡丹江医学院研究生院,中国黑龙江省牡丹江市,牡丹江医学院附属红旗医院眼科,中国黑龙江省牡丹江市,牡丹江医学院附属红旗医院眼科,中国河南省郑州市,中国人民解放军第153中心医院脊柱外科,中国黑龙江省牡丹江市,牡丹江医学院研究生院,中国黑龙江省牡丹江市,牡丹江医学院附属红旗医院眼科 |
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| 基金项目： | 牡丹江医学院研究生创新科研项目(No.2017YJSCX-28MY) |
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| 摘 要： | 糖尿病视网膜病变(diabetic retinopathy，DR)是糖尿病(diabetic melitus，DM)常见且严重的微血管并发症之一。在国外，DR是工作人群(20～64岁)首位的致盲因素； 在国内，DR的发病率和致盲率也在逐年增加，严重影响患者的生存质量。以往对DR发病机制和治疗的研究主要集中在微血管方面，近年来，随着研究的深入，越来越多的学者认为DR不再单纯是一种微血管病变，同时伴随着视网膜神经退行性改变，但国内外文献对DR的微血管病变与神经退行性改变发病机制的研究多是单一的。本文就DR微血管病变与神经退行性改变之间的关系做一综述。
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| 关 键 词： | 糖尿病视网膜病变 微血管病变 神经退行性改变 发病机制 |
| 收稿时间： | 2017/11/10 0:00:00 |
| 修稿时间： | 2018/3/28 0:00:00 |
Research progress on the pathogenesis of microvascular neuropathy in diabetic retinopathy |
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| Dan-Dan Chen,Tian-Jiao Shuai,Juan Li,Xiao-Hang Sun,Rui-Ying Wang and Tian-Hua Piao.Research progress on the pathogenesis of microvascular neuropathy in diabetic retinopathy[J].International Journal of Ophthalmology,2018,18(5):844-846. |
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| Authors: | Dan-Dan Chen Tian-Jiao Shuai Juan Li Xiao-Hang Sun Rui-Ying Wang and Tian-Hua Piao |
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| Institution: | Graduate School of Mudanjiang Medical University, Mudanjiang 157011, Heilongjiang Province, China,Department of Ophthalmology, Hongqi Hospital Affiliated to Mudanjiang Medical University, Mudanjiang 157011, Heilongjiang Province, China,Department of Ophthalmology, Hongqi Hospital Affiliated to Mudanjiang Medical University, Mudanjiang 157011, Heilongjiang Province, China,Department of Spinal Surgery, 153rd Central Hospital of Chinese People''s Liberation Army, Zhengzhou 450000, Henan Province, China,Graduate School of Mudanjiang Medical University, Mudanjiang 157011, Heilongjiang Province, China and Department of Ophthalmology, Hongqi Hospital Affiliated to Mudanjiang Medical University, Mudanjiang 157011, Heilongjiang Province, China |
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| Abstract: | Diabetic retinopathy is one of the common and serious microvascular complications of diabetes. In foreign countries, DR is the leading cause of blindness in the working age group(20-64 years). In China, the incidence of DR and the rate of blindness increase year by year, which seriously affects the patients'' quality of life. Previous studies on the pathogenesis and treatment of diabetic retinopathy were mainly focused on the microvascular; in recent years, with the deepening of researches, more and more scholars believe that DR is no longer simply a kind of microangiopathy, but is also accompanied by retinal neurodegeneration. However, studies on the pathogenesis of microvascular disease and neurodegenerative changes of diabetic retinopathy in the literature domestic and abroad are mostly single. This article reviews the relationship between microvascular disease and neurodegenerative changes in diabetic retinopathy. |
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| Keywords: | diabetic retinopathy microangiopathy neurodegenerative changes pathogenesis |
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