丙戊酸镁联合多奈哌齐对老年痴呆认知行为的影响

目的 探讨丙戊酸镁联合多奈哌齐对老年痴呆认知行为的影响。方法 以2012年9月—2017年9月新疆医科大学第六附属医院60例老年痴呆患者为研究对象，根据随机数字表法将入选的患者平均分为对照组和观察组，每组各30例。患者入院后均嘱其禁止服用记忆增强剂、胰岛素、抗胆碱能及精神兴奋性药物，停药一周后，对照组患者口服盐酸多奈哌齐片5 mg/次，1次/d，每晚睡前服用，连续治疗1周后，剂量增至10 mg/次，1次/d，连续治疗3个月。观察组患者在对照组的基础上联合口服丙戊酸镁缓释片250 mg/次，2次/d，连续治疗3个月。比较两组患者的临床疗效及治疗前后认知功能及精神行为、日常生活能力、抑郁情绪及睡眠质量评分变化。结果 观察组及对照组患者的治疗总有效率分别为86.67%、66.67%，两组比较存在显著差异性（P<0.05）。治疗前两组患者的精神状态检查量表（MMSE）评分、AD评定量表（ADAS）评分、ADL评分、汗密顿抑郁量表（HAMD）评分、匹茨堡睡眠质量指数量表（PSQI）评分比较无显著性差异；治疗后，两组的MMSE、ADL、HAMD、ADAS及PSQI评分均显著降低，同组治疗前后比较差异有统计学意义（P<0.05）；且观察组显著优于对照组，组间差异有统计学意义（P<0.05）。结论 丙戊酸镁联合多奈哌齐可有效提高患者的临床疗效及日常生活能力，改善患者的认知行为、抑郁情绪及睡眠质量，在老年痴呆的治疗中具有重要的应用价值。

Effect of magnesium valproate combined with donepezil in the treatment of Alzheimer's cognitive behavior

Objective To explore effect of magnesium valproate combined with donepezil in the treatment of patients with Alzheimer''s cognitive behavior.Methods 60 patients with Alzheimer''s disease were selected as the subjects from September 2012 to September 2017. According to random number table method, all patients were divided into control group and study group. 30 patients in each group were treated with magnesium valproate treatment, the experimental group on the basis of this combination of donepezil treatment, the clinical effect, cognitive function and mental behavior, daily living ability (ADL), depression mood and sleep quality score changing before and after treatment were observed between two groups.Results The total effective rate in the experimental group were obviously higher than those in the control group (86.67% vs 66.67%) (P<0.05). There were no significant differences in MMSE, ADL, HAMD, ADAS and PSQI scores between the two groups before treatment. After treatment, the MMSE, ADL, HAMD, ADAS and PSQI scores of the two groups were significantly reduced, and the study group was significantly, and the difference was statistically significant (P<0.05). Conclusion Magnesium valproate combined with donepezil in the treatment of patients with Alzheimer''s disease can effectively increase clinical efficacy, daily living ability, and improve the patient''s cognitive behavior, depressive mood, sleep quality, which has important application value.