参芪扶正注射液减轻乳腺癌TC方案骨髓抑制及对患者免疫功能的影响

目的 探讨参芪扶正注射液对乳腺癌TC方案化疗患者骨髓抑制及免疫功能的影响。方法 选取2011年l月-2016年12月开封市中医院收治的乳腺癌患者92例，将所有患者随机分为两组，分别为对照组（46例）、观察组（46例）。对照组采用TC方案化疗，观察组采用TC化疗方案加参芪扶正注射液。所有患者每21天为1个周期，均化疗4周期。化疗4周期后，评价两组患者的骨髓造血功能和免疫功能。结果 在骨髓抑制方面，与化疗前相比，化疗后两组患者均出现白细胞明显减少（P<0.05）；化疗后，观察组白细胞下降的发生率低于对照组，差异有统计学意义（P<0.05）；化疗后，观察组组血红蛋白及白细胞平均恢复天数均明显少于对照组，差异有统计学意义（P<0.05）。在免疫功能方面，化疗后，对照组NK、CD3⁺、CD4⁺、CD8⁺细胞均较治疗前降低，差异有统计学意义（P<0.05）；观察组NK、CD3⁺、CD4⁺、CD4⁺/CD8⁺均较化疗前升高，差异均具有统计学意义（P<0.05），CD8⁺升高不明显；化疗后观察组NK、CD3⁺、CD4⁺、CD8⁺、CD4⁺/CD8⁺均高于对照组，差异均具有统计学意义（P<0.05）。结论 参芪扶正注射液可减轻TC方案化疗引起的骨髓抑制，增强患者的免疫功能。

The clinical effects of the Shenqi Fuzheng injection on bone marrow suppression and immune function after TC scheme in treatment of patients with breast cancer

Objective To investigate the clinical effects of the Shenqi Fuzheng injection on bone marrow suppression and immune function after TC scheme in treatment of patients with breast cancer. Methods 92 patients with breast cancer in our hospital was choose from January 2011 to December 2016. 92 patients were randomly divided into two groups:the control group (46cases) and the observation group (46 cases).The patients in the control group were administered with TC regimen. The patients in the observation group were treated with TC regimen plus Shenqifuzheng injection. The cycle of chemotherapy was 21d,and total four cycles were performed for all patients. Bone marrow suppression and immune function were evaluated after 4 cycles of chemotherapy in two groups. Results In the bone marrow suppression, white blood cell after chemotherapy was significantly decreased in all patients compared with before chemotherapy (P<0.05), the differences were statistically significant; the incidence of leukocytopenia in the observation group was lower than the control group after chemotherapy (P<0.05), the differences were statistically significant; and average time of recovery in the observation group was shorter than the control group for the hemoglobin and white blood cell, the differences were statistically significant (P<0.05). In immune function in the observation group, NK, CD3⁺,CD4⁺, CD4⁺/CD8⁺ were higher compared with before chemotherapy, the differences were statistically significant (P<0.05), CD8⁺ was increased, but not obviously. After chemotherapy, the NK cell, CD3⁺, CD4⁺, CD8⁺, CD4⁺/CD8⁺ in the observation group were all higher than those in the control group, the differences were statistically significant (P<0.05). Conclusions The Shenqi Fuzheng injection could reduce bone marrow suppression after TC scheme in treatment of patients with breast cancer, and enhance cellular immune function.