红花注射液联合重组组织型纤溶酶原激活剂对急性脑梗死的疗效、血液流变学和血脂的影响

目的 研究红花注射液联合重组组织型纤溶酶原激活剂（rt-PA）对急性脑梗死的疗效、血液流变学和血脂的影响。方法 选择2014年1月—2017年6月新疆建设兵团额敏第九师医院的90例急性脑梗死患者，随机分为两组。对照组给予rt-PA 0.9 mg/kg进行溶栓治疗，观察组在对照组给药基础上联合静脉滴注红花注射液40 mL，比较两组治疗前后的血小板聚集率、血黏稠度等血液流变学参数以及总胆固醇（TC）、低密度脂蛋白（LDL）、三酰甘油（TG）等血脂指标，ADL量表评分以及NIHSS量表评分。结果 观察组的有效率为93.34%，明显高于对照组的73.34%，差异有统计学意义（P<0.05）；治疗后两组的血小板聚集率和血黏稠度均明显降低，同组治疗前后比较差异有统计学意义（P<0.05），且观察组明显低于对照组，差异有统计学意义（P<0.05）。两组治疗后的TC、LDL、TG均明显改善，同组治疗前后比较差异有统计学意义（P<0.05），且观察组明显优于对照组，差异有统计学意义（P<0.05）。两组治疗后的ADL量表评分明显升高（P<0.05），NIHSS量表评分明显降低，同组治疗前后比较差异有统计学意义（P<0.05），且观察组更为明显（P<0.05）。结论 红花注射液联合rt-PA对急性脑梗死的治疗效果明显优于单纯使用rt-PA，可以改善患者的血液流变学，降低血脂，从而有效改善患者的日常生活能力和神经功能。

Influence of efficacy, hemorheology, blood lipid of Safflower Injection combeind with recombinant tissue plasminogen activator on patients with acute cerebral infarction

Objective To investigate the influence of efficacy, hemorheology, blood lipid of Safflower Injection combeind with recombinant tissue plasminogen activator on patients with acute cerebral infarction. Methods From Jan. 2014 to June 2017, 90 cases with acute cerebral infarction in our hospital were chosen and randomly divided into two groups. The control group were given rt-PA 0.9 mg/kg on thrombolytic therapy, the observation group were given Safflower Injection (40 mL) combined with recombinant tissue plasminogen activator, the blood rheological parameters of platelet aggregation, blood viscosity and blood lipid (TC, LDL, TG) were compared, the ADL scale score and NIHSS scale score of two groups were compared. Results The efficacy of observation group was higher than control group (P<0.05), the platelet aggregation and blood viscosity of two groups after treatment were decreased (P<0.05), while the observation group was decreased obviously than control group (P<0.05); the ADL scale score of two groups after treatment were higher (P<0.05), NIHSS scale score were all decreased (P<0.05), while the observation group was decreased obviously (P<0.05). Conclusion The Safflower Injection combined with recombinant tissue plasminogen activator had better efficacy on acute cerebral infarction than rt-PA, which could improve the hemorheology, decrease the blood lipid, and improve the daily life and neurological function.