参附注射液联合小剂量糖皮质激素治疗感染性休克的临床效果分析

目的 研究参附注射液联合小剂量糖皮质激素治疗感染性休克的临床效果。方法 选择2013年1月-2017年1月在新疆阿克苏第一人民医院进行诊治的感染性休克患者94例，随机分为两组，每组各47例。对照组给予小剂量糖皮质激素治疗，观察组在对照组基础上给予参附注射液治疗，两组均持续治疗2 d。比较两组的临床治疗效果，治疗前、治疗后1 d和治疗后2 d的白介素-6、肿瘤坏死因子-α以及血液乳酸水平；观察两组的住院时间，并随访半年，记录两组患者的多脏器功能不全发生率以及病死率。结果 观察组的有效率为91.49%（43/47），明显高于对照组的76.59%（36/47），差异有统计学意义（P<0.05）。两组治疗后1 d和治疗后2 d的白介素-6和肿瘤坏死因子-α水平均明显降低，同组治疗前后比较差异有统计学意义（P<0.05），且观察组明显低于对照组，差异有统计学意义（P<0.05）。两组治疗后1 d和治疗后2 d的血乳酸水平均明显降低，同组治疗前后比较差异有统计学意义（P<0.05）；且观察组明显低于对照组，差异有统计学意义（P<0.05）。观察组的住院时间以及多脏器功能不全发生率明显低于对照组，差异有统计学意义（P<0.05）。结论 参附注射液联合小剂量糖皮质激素治疗感染性休克的临床效果明显优于单纯采用西药治疗，能有效改善患者的血乳酸和炎症因子水平，并具有较高的安全性，适合推广应用。

Clinical analysis of Shenfu Injection combined with small dose of glucocorticoid in the treatment of septic shock

Objective To investigate the clinical effect of Shenfu Injection combined with small dose of glucocorticoid in the treatment of septic shock.Methods Selected 94 cases of patients with septic shock who were treated in our hospital from January 2013 to January 2017, divided into two groups randomly. The control group was treated with small dose of glucocorticoid, and the observation group was treated with Shenfu Injection. The clinical therapeutic effect of two groups were compared, interleukin -6, tumor necrosis factor alpha and blood lactate levels before and after treatment were compared, and followed up for half a year, recorded multiple organ function of the two groups of patients the incidence and mortality rate.Results After treatment, the effective rate of the observation group was 91.49% (43/47), significantly higher than that of the control group 76.59% (36/47) (P < 0.05); the levels of interleukin -6 and tumor necrosis factor alpha after treatment were significantly lower in the two groups (P < 0.05) than in the observation group (P < 0.05); the blood lactate level were significantly decreased after treatment (P < 0.05), and the observation group was more significant (P < 0.05); hospitalization time of the observation group and multi organ dysfunction was significantly lower than the control group (P < 0.05).Conclusion Shenfu Injection combined with small dose of glucocorticoid in the treatment of septic shock is better than the simple use of western medicine treatment, can effectively improve the patient''s blood lactic acid and the levels of inflammatory factors, and has high security.