| 乌索酸调节PI3K/AKT/mTOR信号通路在结直肠癌中的研究进展 |
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| 引用本文： | 崔宏伟,苏秀兰.乌索酸调节PI3K/AKT/mTOR信号通路在结直肠癌中的研究进展[J].世界科学技术-中医药现代化,2018,20(10):1882-1888. |
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| 作者姓名： | 崔宏伟 苏秀兰 |
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| 作者单位： | 内蒙古医科大学附属医院临床医学研究中心 呼和浩特市 010050,内蒙古医科大学附属医院临床医学研究中心 呼和浩特市 010050 |
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| 基金项目： | 国家自然科学基金地区科学基金项目（81660468）：生物活性肽ACBP介导miRNA调节胃癌干细胞作用机制及功能研究，负责人：苏秀兰 |
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| 摘 要： | 乌索酸（Ursolic acid，UA）是一种广泛存在于植物的草、叶、花和果实中的具有抗氧化，抗菌，抗炎，肝保护，免疫调节，抗肿瘤，化学预防，心脏保护、抗高脂血症和降低血糖等活性的五环三萜类化合物。本文综述了乌索酸结构与抗肿瘤机制、PI3K/AKT/mTOR信号通路参与结直肠癌进程以及乌索酸调节PI3K/AKT信号通路阻碍结直肠癌进展。
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| 关 键 词： | 乌索酸 PI3K/AKT信号通路 结直肠癌 |
Progress in the Regulation of PI3K/AKT/mTOR Signaling Pathway by Ursolic Acid in Colorectal Cancer |
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| Cui Hongwei and Su Xiulan.Progress in the Regulation of PI3K/AKT/mTOR Signaling Pathway by Ursolic Acid in Colorectal Cancer[J].World Science and Technology-Modernization of Traditional Chinese Medicine,2018,20(10):1882-1888. |
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| Authors: | Cui Hongwei and Su Xiulan |
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| Institution: | The Clinical Medical Research Center of the Affiliated Hospital of Inner Mongolia Medical University, Hohhot, Inner Mongolia 010050, China and The Clinical Medical Research Center of the Affiliated Hospital of Inner Mongolia Medical University, Hohhot, Inner Mongolia 010050, China |
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| Abstract: | Ursolic acid (UA) is an active pentacyclic triterpenoid widely found in grass, leaves, flowers and fruits of plants, which is antioxidant, antimicrobial, anti- inflammatory, hepatoprotective, immunomodulatory, anti- tumor,chemopreventive, cardioprotective and antihyperlipidemic and hypoglycemic. In paper, the ursolic acid structure, antitumormechanism, PI3K/AKT/mTOR signaling pathway taking part in the process of colorectal cancer, and the regulationof PI3K/AKT/mTOR signaling pathway by ursolic acid in stopping the development of colorectal cancer was summarized. |
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| Keywords: | Ursolic acid PI3K/AKT/mTOR signaling pathway colorectal cancer |
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