高度近视白内障患者手术前后眼生物测量参数相关性分析

目的：对高度近视白内障患者手术前后眼生物测量参数进行分析，为高度近视白内障的人工晶状体屈光度计算公式提供参考。

方法：选取2011-01/2017-05我院收治的152眼高度近视白内障患者，所有患眼眼轴≥26mm，测量白内障手术前眼轴长度、角膜曲率、前房深度、晶状体厚度，以及手术后3mo角膜曲率、前房深度。分析各参数之间相互关系，并对术后前房深度进行多元线性回归分析。

结果：术前眼轴长度与术前角膜曲率、晶状体厚度呈正相关(r=0.236、0.216，P<0.05)。术前眼轴长度与术前前房深度无相关关系(P>0.05)。术前前房深度与术前角膜曲率无相关关系(P>0.05)。术前前房深度与术前晶状体厚度呈负相关关系(r=-0.513，P<0.05)。术后前房深度与术前眼轴长度、术前前房深度、术前角膜曲率、术后角膜曲率呈正相关关系(r=0.374、0.364、0.333、0.356，P<0.05)。术后前房深度与术前晶状体厚度无相关关系(P>0.05)。术后前房深度的多元线性回归方程为：术后前房深度=-2.592+0.091×术前眼轴长度+0.078×术前角膜曲率+0.491×术前前房深度。

结论：通过测量术前眼轴长度、角膜曲率、前房深度，利用术后前房深度多元回归方程，可以计算出术后前房深度，从而为高度近视白内障患者术后人工晶状体屈光度计算公式提供参考。

Correlation analysis of ocular biological parameters of cataract eyes with high myopia before and after cataract surgery

AIM: To analyze the biometric parameters before and after cataract surgeries of the cataract eyes with high myopia, and to provide reference for the calculation of intraocular lens diopter for cataract eyes with high myopia.

METHODS: Totally 152 cataract eyes with high myopia were selected. All the axial lengths were equal to or more than 26mm. The preoperative axial length, corneal curvature, anterior chamber depth, and lens thickness were measured before cataract surgery, and also the corneal curvature and anterior chamber depth were measured 3mo after cataract surgery. The relationships between the parameters were analyzed, and the postoperative anterior chamber depth was analyzed by multiple linear regression analysis.

RESULTS: The correlation between the preoperative axial length and preoperative corneal curvature, lens thickness was positive separately(r=0.236, r=0.216; P<0.05). There was no correlation between preoperative axial length and preoperative anterior chamber depth(P>0.05). And there was no correlation between preoperative anterior chamber depth and preoperative corneal curvature(P>0.05). There was negative correlation between preoperative anterior chamber depth and preoperative lens thickness(r=-0.513, P<0.05). And there was positive correlation between postoperative anterior chamber depth and preoperative axial length, preoperative anterior chamber depth, preoperative corneal curvature and postoperative corneal curvature separately(r=0.374, r=0.364, r=0.333, r=0.356; P<0.05). There was no correlation between postoperative anterior chamber depth and preoperative lens thickness(P>0.05). The multiple linear regression equation was: postoperative anterior chamber depth = -2.592 + 0.091 × preoperative axial length +0.078 × preoperative corneal curvature +0.491 × preoperative anterior chamber depth.

CONCLUSION: By measuring the preoperative axial length, corneal curvature and anterior chamber depth, the postoperative anterior chamber depth can be calculated by using the postoperative anterior chamber depth multiple regression equation, so as to provide a reference for the calculation formula of intraocular lens diopter of cataract patients with high myopia.