2014—2017年六安市人民医院中药注射剂致不良反应分析

目的 调查分析六安市人民医院中药注射剂致药品不良反应（ADR）发生的一般规律及特点，为临床中药注射剂合理用药提供参考。方法 主要对2014-2017年六安市人民医院收集上报国家药品不良反应监测系统中的104份中药注射剂ADR报告进行统计分析。结果 中药注射剂不良反应104例，其中男58例，女46例；其中50~59、60~69岁年龄段的ADR例数最多，占比均为23.08%；ADR发生在用药后10~30 min较多，占35.58%；中药注射剂引发不良反应的主要表现为皮肤损害和全身性症状，其中以皮肤损害比例最高，达57.69%，其次为全身性症状，占18.27%。较严重的药品不良反应有过敏性休克、呼吸困难、剥脱性皮炎等。造成中药注射剂不良反应构成比最高的为生脉注射液，占比为19.23%。结论 临床应加强中药注射剂ADR的监测与上报工作，减少和避免不良反应的重复发生，保障患者用药安全，促进合理用药。

Analysis on adverse reactions of caused by traditional Chinese medicine injection in Lu'an People's Hospital from 2014 to 2017

Objective To and analyze the general patterns and characteristics of adverse drug reactions (ADR) caused by traditional Chinese medicine injections in the Lu''an People''s Hospital, and to provide references for the rational use of traditional Chinese medicine injections.Methods 104 Cases of ADR reports on Chinese medicine injections in Lu''an People''s Hospital from 2014 to 2017 to National ADR Monitoring C enter were selected and analyzed.Results There were 104 cases of adverse reactions to traditional Chinese medicine injections, including 58 cases in males and 46 cases in females. The number of ADR cases was the highest in 50-59 and 60-69 age groups, accounting for 23.08% of the total. Most ADR occurred in 10-30 min after administration, accounting for 35.58%. The main manifestations of adverse reactions induced by Chinese medicine injections were skin lesions and systemic symptoms, with the highest proportion of skin lesions (57.69%), followed by systemic symptoms, accounting for 18.27%. The more serious adverse drug reactions were anaphylactic shock, dyspnea, and exfoliative dermatitis. The proportion of ADR caused by Chinese medicine injections was 19.23% of Shengmai Injection.Conclusion In clinical practice, the monitoring and reporting of ADR should be strengthened to reduce and avoid the recurrence of adverse reactions, ensure the safety of patients'' medication and promote the rational use of drugs.