乳酸菌素片联合莫沙必利治疗功能性消化不良的临床研究

目的探讨乳酸菌素片联合莫沙必利治疗功能性消化不良的临床研究。方法选取2016年6月—2018年6月南京鼓楼医院集团宿迁市人民医院收治的100例功能性消化不良患者,随机分成对照组和治疗组,每组各50例。对照组口服枸橼酸莫沙必利片,5mg/次,3次/d。治疗组在对照组治疗基础上口服乳酸菌素片,2片/次,3次/d。两组均连续治疗4周。观察两组的临床疗效,比较两组治疗前后症状积分、功能性消化不良生存质量量表(FDDQL)评分、胃排空率及胃肠激素的变化情况。结果治疗后,对照组和治疗组的总有效率分别是80.0%、94.0%,两组比较差异具有统计学意义(P0.05)。治疗后,两组早饱感评分、中上腹烧灼感评分、中上腹痛评分、餐后饱胀不适评分及总分均显著降低,同组治疗前后比较差异有统计学意义(P0.05);治疗后,治疗组这些症状评分均显著低于对照组,两组比较差异具有统计学意义(P0.05)。治疗后,治疗后两组日常活动评分、饮食评分、不适评分、疾病控制评分、忧虑评分、睡眠评分、健康感觉评分、压力评分和总评分均显著升高,同组治疗前后比较差异有统计学意义(P0.05);治疗后,治疗组FDDQL各领域评分显著高于对照组,两组比较差异具有统计学意义(P0.05)。治疗后,两组胃排空率、胃动素(MLT)均较治疗前显著增加,但血浆胃泌素(GAS)显著降低,同组治疗前后比较差异有统计学意义(P0.05);治疗后,治疗组胃排空率、MLT水平显著高于对照组,GAS水平显著低于对照组,两组比较差异具有统计学意义(P0.05)。结论乳酸菌素片联合莫沙必利治疗功能性消化不良具有较好的临床疗效,可明显减轻患者症状,正性调节胃肠激素分泌,提高生活质量,具有一定的临床推广应用价值。

Clinical study of Lacidophilin Tablets combined with mosapride in treatment of functional dyspepsia

Objective To investigate the clinical efficacy of Lacidophilin Tablets combined with mosapride in treatment of functional dyspepsia. Methods Patients (100 cases) with functional dyspepsia in Suqian People''s Hospital of Nanjing Drum-Tower Hospital Group from June 2016 to June 2018 were randomly divided into control (50 cases) and treatment (50 cases) groups. Patients in the control group were po administered with Mosapride Citrate Tablets, 5 mg/time, three times daily. Patients in the treatment group were po administered with Lacidophilin Tablets on the basis of the control group, 2 tablets/time, three times daily.. Patients in two groups were treated for 4 weeks. After treatment, the clinical efficacy was evaluated, and the changes of symptom score, FDDQL score, gastric emptying rate and gastrointestinal hormones in two groups before and after treatment were compared. Results After treatment, the clinical efficacy in the control and treatment group were 80.0% and 94.0%, and there were differences between two groups (P<0.05). After treatment, early satiety score, middle and upper abdominal burning score, middle and upper abdominal painscore score, postprandial fullness discomfort score and total score in the two groups were significantly reduced, and there were differences in the same group (P<0.05). After treatment, the symptom scores in the treatment group were lower than those in the control group, and there were differences between two groups (P<0.05). After treatment, daily activities score, diet score, discomfort score, disease control score, anxiety score, sleep score, health sensation score, stress score and total score were significantly increased, and there were differences in the same group (P<0.05). After treatment, FDDQL scores in the treatment group were higher than those in the control group, and there were differences between two groups (P<0.05). After treatment, gastric emptying rate and MLT in two groups were significantly increased, but GAS was significantly decreased, and there were differences in the same group (P<0.05). After treatment, gastric emptying rate and MLT in the treatment group were higher than those in the control group, but GAS was lower than those in the control group, and there were differences between two groups (P<0.05). Conclusion Lacidophilin Tablets combined with mosapride has significant clinical effect in treatment of functional dyspepsia, and can significantly relieve symptoms, also can regulate positively gastrointestinal hormones, and improve life quality, which has a certain clinical application value.