可降解锌合金冠状动脉支架研发进展

继金属裸支架、药物洗脱支架阶段后,可降解支架正在成为冠心病治疗和介入医学工程领域的研究热点。锌合金具有更为理想的降解速率和降解特性,其作为可降解冠状动脉支架近年来受到关注。本文介绍了可降解锌合金材料的合金化元素、力学性能、降解性能、生物相容性、动物实验研究现状,并展望了锌合金作为可降解冠状动脉支架材料的发展前景及我国锌合金冠状动脉支架的研究趋势、产业化前景。

Research and development progress on biodegradable zinc-based coronary stents

Biodegradable stents are becoming the research focus in both fields of interventional medical engineering and treatment of coronary heart disease (CHD) after the bare-metal stents (BMS) and drug-eluting stents (DES). In recent years, zinc-based alloys attracted increasing attention for its appropriate degradation rate and degradation behavior. The status of alloying elements, mechanical properties, degradation, biocompatibility, and animal studies of the zinc-based alloys are introduced in this review. The development prospect of zinc-based alloys as a degradable coronary stent material, and the research trend and industrialization prospect of zinc-based alloys coronary stent in China are prospected.