2015—2017年咸阳市中心医院住院患者抗菌药物的使用情况分析

目的 分析2015-2017年咸阳市中心医院住院患者抗菌药物的使用情况，为进一步保障用药安全提供参考依据。方法 调取2015年1月-2017年12月咸阳市中心医院住院患者抗菌药物应用的相关数据，对抗菌药物的使用率、用药品种、销售金额、用药频度（DDDs）和使用强度（AUD）等数据进行统计分析。结果 2015-2017年，抗菌药物使用率均低于60%，使用强度控制欠佳。用药品种更倾向于选择疗效确切、抗菌谱广、安全性高的抗菌药物，头孢菌素类的DDDs连续3年排名第1位，其次是喹诺酮类和硝基咪唑类药物。使用金额排名前3位的均为头孢菌素类、青霉素类和碳青霉烯类。注射用头孢哌酮钠舒巴坦钠的使用金额和DDDs均居于第1位。结论 2015-2017年咸阳市中心医院住院患者抗菌药物的使用基本合理，但仍存在部分问题，需引起全员重视，进一步细化管理，建立长效机制，继续加强细菌耐药监测和抗菌药物临床应用管理促进抗菌药物的合理使用。

Analysis on utilization of antimicrobial drugs of inpatients in Xianyang Central Hospital from 2015 to 2017

Objective To analyze the utilization of antimicrobial drugs of inpatients in Xianyang Central Hospital from 2015 to 2017, and to provide reference basis for further protection of drug safety.Methods The related data of the utilization of antimicrobial drugs of inpatients in Xianyang Central Hospital from 2015 to 2017 were collected, and the usage rate, drug varieties, consumption sum, defined daily doses (DDDs), and use intensity (AUD) were analyzed statistically. Results The utilization ratio of antimicrobial drugs was lower than 60%, while AUD was poorly controlled. Drugs with high efficacy, wide antibacterial spectrum, and high safety were more likely to chosen. DDDs of cephalosporins were ranked the first for three consecutive years, and then were quinolones and nitroimidazoles. Consumption sums of cephalosporins, penicillins, and carbapenems were ranked the top three. Consumption sum and DDDs of Cefoperazone Sulbactam for injection were ranked the first. Conclusion The utilization of antimicrobial drugs of inpatients in Xianyang Central Hospital from 2015 to 2017 is reasonable on the whole, while there were always some problems, which need to be took into account. The management should be further refinement, and long-term mechanism should be established. Bacterial resistance monitoring and clinical application management of antimicrobial drugs should be strengthened to promote rational drug use in clinic.