槐杞黄颗粒联合阿奇霉素治疗老年支原体肺炎的临床研究

目的探讨槐杞黄颗粒联合阿奇霉素治疗老年支原体肺炎的临床疗效。方法选取2017年1月—2018年3月淮北市人民医院收治的老年支原体肺炎患者96例为研究对象,按照随机数字表法分为对照组和治疗组,每组各48例。对照组在第1～3天静脉滴注注射用阿奇霉素,0.5 g加入到生理盐水500 mL中,1次/d;在第4～10天口服阿奇霉素片,0.25 g/次,1次/d。治疗组在对照组治疗的基础上温水冲服槐杞黄颗粒,10g/次,2次/d。两组患者均连续治疗10d。观察两组的临床疗效,比较两组的症状体征消失时间和T淋巴细胞亚群指标水平。结果治疗后,对照组和治疗组的总有效率分别为77.08%、91.67%,两组比较差异有统计学意义(P0.05)。治疗后,治疗组咳嗽、头痛、发热、肺部阴影消失时间明显短于对照组,两组比较差异有统计学意义(P0.05)。治疗后,两组CD3+、CD4+、CD4+/CD8+、自然杀伤(NK)细胞水平明显升高,同组治疗前后比较差异有统计学意义(P0.05);且治疗组T淋巴细胞亚群指标水平明显高于对照组,两组比较差异具有统计学意义(P0.05)。结论槐杞黄颗粒联合阿奇霉素治疗老年支原体肺炎具有较好的临床疗效,可改善临床症状,调节T淋巴细胞水平,增强免疫功能,具有一定的临床推广应用价值。

Clinical study on Huaiqihuang Granules combined with azithromycin in treatment of mycoplasma pneumonia in the elderly

Objective To investigate the clinical efficacy of Huaiqihuang Granules combined with azithromycin in treatment of mycoplasma pneumonia in the elderly. Methods Elderly patients (96 cases) with mycoplasma pneumonia in Huaibei People''s Hospital from January 2017 to March 2018 were randomly divided into control and treatment groups, and each group had 48 cases. At the first to third day, patients in the control group were iv administered with Azithromycin for injection, 0.5 g added into normal saline 500 mL, once daily. And at the fourth to tenth day, patients in the control group were po administered with Azithromycin Tablets, 0.25 g/time, once daily. Patients in the treatment group were po administered with Huaiqihuang Granules on the basis of the control group, 10 g/time, twice daily. Patients in two groups were treated for 10 d. After treatment, the clinical efficacies were evaluated, and disappearance time of symptoms and signs, levels of T lymphocyte subsets in two groups were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 77.08% and 91.67%, respectively, and there was difference between two groups (P<0.05). After treatment, the disappearance times of cough, headache, fever, and lung shadow in the treatment group were shorter than those in the control group, and there was difference between two groups (P<0.05). After treatment, CD3⁺, CD4⁺, CD4⁺/CD8⁺, and NK in two groups were significantly increased, and the difference was statistically significant in the same group (P<0.05). And the T lymphocyte subsets indexes in the treatment group were significantly higher than those in the control group, with significant difference between two groups (P<0.05). Conclusion Huaiqihuang Granules combined with azithromycin has clinical curative effect in treatment of mycoplasma pneumonia in the elderly, can improve clinical symptoms, regulate T lymphocyte level, and enhance immune function, which has a certain clinical application value.