艾拉莫德联合甲氨蝶呤治疗类风湿性关节炎临床研究

目的 研究艾拉莫德联合甲氨蝶呤治疗类风湿性关节炎临床效果。方法 选择2015年1月-2017年11月在揭阳市人民医院进行诊治的60例类风湿性关节炎患者，随机分为两组。对照组口服甲氨蝶呤治疗，每次10 mg，每天1次；观察组联合口服艾拉莫德治疗，每次25 mg，每天2次。两组均治疗3个月。比较两组的临床治疗效果，并比较两组治疗前后的血清C反应蛋白、类风湿因子、抗环瓜氨酸肽抗体和红细胞沉降率，以及白介素-6、淋巴细胞绝对值、免疫球蛋白G。结果 观察组的有效率90.00%高于对照组70.00%，差异有统计学意义（P<0.05）。治疗后两组的血清C反应蛋白、类风湿因子、抗环瓜氨酸肽抗体和红细胞沉降率均明显降低，同组治疗前后比较差异有统计学意义（P<0.05）；且观察组明显低于对照组，组间差异有统计学意义（P<0.05）。治疗后两组的淋巴细胞绝对值、免疫球蛋白G、白介素-6均明显降低，同组治疗前后比较差异有统计学意义（P<0.05）；且观察组明显低于对照组，组间差异有统计学意义（P<0.05）。两组的不良反应率相比无明显差异。结论 艾拉莫德联合甲氨蝶呤治疗类风湿性关节炎临床效果显著，是一种安全有效的治疗方案。

Clinical analysis of methotrexate combined with iguratimod in the treatment of rheumatoid arthritis

Objective To investigate the clinical effect ofmethotrexate combined with iguratimod in the treatment of rheumatoid arthritis.Methods Selected 60 cases of patients with rheumatoid arthritis who were treated in our hospital from January 2015 to November 2017, divided into two groups randomly. The control group was treated with methotrexate, 10 mg each time, 1 times a day. The observation group was treated with oral iguratimod, 25 mg each time, 2 times a day. The clinical therapeutic effect of two groups were compared, and compared the serum C reactive protein, rheumatoid factor and anti-cyclic citrullinated peptide antibody and erythrocyte sedimentation rate, interleukin -6, LYMPH, immunoglobulin G.Results After treatment, the effective rate of the observation group was 90.00% (27/30), which was higher than 70.00% of the control group (21/30) (P < 0.05); after treatment, serum C reactive protein,, rheumatoid factor, anti-cyclic citrullinated peptide antibody and erythrocyte sedimentation rate of the two groups were significantly lower (P < 0.05), and the observation group was more obvious (P < 0.05); the levels of interleukin-6, immunoglobulin G, LYMPH in the two groups were significantly lower (P < 0.05), and the observation group was more obvious (P < 0.05). There was no significant difference in the adverse reaction rate between the two groups.Conclusion Methotrexate combined with iguratimod in the treatment of rheumatoid arthritis clinical effect is significant, is a safe and effective treatment.