2014—2017年黄石市中心医院质子泵抑制剂的使用情况分析

目的 了解2014-2017年黄石市中心医院质子泵抑制剂（PPIs）的用药现状和发展趋势，为临床合理用药提供参考。方法 采用限定日剂量法（DDD），对黄石市中心医院PPIs的用药金额、用量、用药频度（DDDs）、限定日费用（DDC）、和排序比（B/A）等指标进行回顾性分析。结果 PPIs使用呈逐年上升趋势，第1代PPIs的用量占据显著优势，注射剂型的用药金额远高于口服剂型。注射剂型中泮托拉唑的DDC最低，用药金额和DDDs连续4年排第1位；兰索拉唑的用药金额增长最快。口服剂型中艾司奥美拉唑镁肠溶片的用药金额连续4年排第1位；泮托拉唑钠肠溶胶囊的DDC最低，B/A连续4年最高。结论 黄石市中心医院PPIs的临床使用基本合理，但存在倾向于使用第1代PPIs及注射剂比重过大等现象，应规范和完善PPIs的临床管理与应用。

Analysis on application of proton pump inhibitors in Huangshi Central Hospital from 2014 to 2017

Objective To investigate the use of proton pump inhibitors (PPIs) in Huangshi Central Hospital from 2014 to 2017, so as to provide reference for clinical rational use of drugs. Methods The consumption sum, dosage, defined daily doses (DDDs), defined daily cost (DDC), and drug sequence ratio (B/A) of PPIs were statistically analyzed by defined daily dose method (DDD). Results The use of PPIs was increasing year by year. The amounts of first generation of PPIs occupied a significant advantage, and the amount of injection type was much higher than that of the oral dosage form. DDC of pantoprazole in injection type was the lowest, and consumption sum and DDDs ranked the first in four consecutive years. Consumption sum of lansoprazole had the fastest growth. Consumption sum of Esomeprazole Magnesium Enteric-coated Tablets in the oral dosage form ranked the first in four consecutive years. DDC of Pantoprazole Sodium Enteric-coated Capsules was the lowest with the highest B/A for four consecutive years. Conclusion The clinical use of PPIs in Huangshi Central Hospital is basically reasonable, but there is a tendency to use the first generation of PPIs and the proportion of injection is too large. The clinical management and application of PPIs should be standardized and improved.