血小板/淋巴细胞比值与老年2型糖尿病患者颈动脉粥样硬化的关系

目的 探讨在老年2型糖尿病（T2DM）患者中血小板/淋巴细胞比值（PLR）与颈动脉粥样硬化的关系。方法 选取2015年6月至2017年6月河南科技大学第一附属医院内分泌科住院的老年T2DM患者220例，根据彩色多普勒超声检查结果，将双侧颈动脉正常者为正常组（共118例），颈动脉有粥样硬化者为硬化组（共102例），检测血常规、血脂、血糖等，计算PLR，比较两组患者PLR、血脂、血糖等差异。采用Pearson相关分析及logistic回归分析进行PLR与颈动脉粥样硬化的相关性分析。结果 硬化组患者年龄、收缩压、血小板计数（PLT）、PLR、低密度脂蛋白胆固醇（LDL-C）、总胆固醇（TC）、空腹血糖（FBG）、糖化血红蛋白（HbA1c）和颈动脉内膜中层厚度（CIMT）均高于正常组，而淋巴细胞计数（LC）低于正常组，差异均有统计学意义（P<0.05）；Pearson相关分析提示，CIMT与年龄、收缩压、PLR、LDL-C、TC、FBG和HbA1c呈正相关（P<0.05）；多元逐步回归分析提示CIMT与PLR密切相关；logistic回归分析提示，在校正部分危险因素如年龄、血糖、血脂等后，PLR仍然是老年T2DM患者患颈动脉粥样硬化的危险因素；ROC曲线分析发现，PLR的曲线下面积为0.793，其截断值取100.12时，诊断动脉粥样硬化的敏感度为79.80%，特异度为65.10%。结论 PLR是老年T2DM患颈动脉粥样硬化的独立危险因素。

Associationbetween platelet-to-lymphocyte ratio and carotid atherosclerosis in elderly patients with type 2 diabetes mellitus

Objective To investigate the possibility of platelet-to-lymphocyte ratio (PLR) as a biomarker for carotid atherosclerosis in elderly patients with type 2 diabetes (T2DM). Methods From Jun 2015 to Jun 2017, 220 elderly patients with T2DM hospitalized in our hospital were enrolled in the study and divided into two groups:patients without carotid atherosclerosis were the normal group (n=118), and those with carotid atherosclerosis the atherosclerosis group (n=102). The lymphocyte, platelet, lipid and glucose in these individuals were determined and compared. And the correlation between PLR and carotid atherosclerosis was performed by Pearson analysis and logistic regression analysis. Results Compared with normal group, age, systolic pressure, PLT, PLR, LDL-C, TC, FBG, HbA1c and CIM T were higher in atherosclerosis group, while LC was lower (P<0.05). CIMT was positively correlated with age, systolic pressure, PLR, LDL-C, TC, FBG and HbA1c(P<0.05). In multiple linear regression analyses, after adjustment for age, lipid, glucose and so on, PLR was also positively correlated with CIMT. Logistic multiple regression analysis showed that after adjustment for risk factors, PLR was the independent variable for predicting carotid atherosclerosis in elderly patients with T2DM. According to the analysis of ROC curve, the cut off value of carotid atherosclerosis was set at 100.12, with the sensitivity of 79.80% and the specificity of 65.10%.Conclusion PLR is an independent risk factor for carotid atherosclerosis in elderly patients with T2DM.