中药心舒合剂联合盐酸舍曲林治疗抑郁症的疗效评价

目的] 研究中药心舒合剂联合盐酸舍曲林治疗抑郁症患者的临床效果及安全性。方法] 纳入抑郁症患者100例，随机分为观察组和对照组，各50例。观察组给予心舒合剂联合盐酸舍曲林治疗，对照组仅给予盐酸舍曲林。记录并分析患者用药治疗前后的汉密尔顿抑郁量表（HAMD）评分、治疗前后血清脑源性神经营养因子（BDNF）水平及不良反应发生状况。结果] 1）治疗8周及12周后观察组HAMD评分分别为（10.52±1.83）分、（6.91±1.04）分，均优于对照组的（18.72±2.27）分、（11.58±1.74）分，且差异具有统计学意义（P<0.05）。2）治疗后观察组血清BDNF水平为（1 288.86±468.40） pg/mL优于对照组的（1 183.27±362.52） pg/mL，且差异具有统计学意义（P<0.05）。3）观察组总体治疗有效率（84.0%）高于对照组（70.0%），且差异具有统计学意义（P<0.05）。4）观察组嗜睡发生率低于对照组，且差异有统计学意义（P<0.05）。结论] 心舒合剂联合盐酸舍曲林治疗抑郁症的临床效果确切不良反应低，值得临床进一步深入研究和推广。

Clinical observation of combination therapy of traditional Chinese medicine Xinshu mixture and Sertraline Hydrochloride for the treatment of depression

Objective] To study the clinical observation of combination therapy of traditional Chinese medicine Xinshu mixture and Sertraline Hydrochloride for the treatment of depression.Methods] The 100 patients were randomly divided into observation group and control group and 50 cases for each. The observation group was given Xinshu mixture combined Sertraline Hydrochloride, and the control group received only Sertraline Hydrochloride. Patients'' HAMD score, serum BDNF levels and situation of untoward reaction were recorded and analyzed before and after treatment.Results] 1) After 8 weeks and 12 weeks treatment, HAMD score of observation group was (10.52±1.83) and (6.91±1.04), it was better than the control group (18.72±2.27) and (11.58±1.74), and the difference was statistically significant (P<0.05). 2) The serum BDNF level of the observation group was (1 288.86 ±468.40) pg/mL, which was better than the control group (1 183.27±362.52) pg/mL after treatment, and the difference was significant (P<0.05). 3) As for the overall therapeutically effectiveness, observation group reached 84.0%, which was much higher than the control group 70.0%, and the difference was statistically significant (P<0.05). 4) The incidence rate of drowsiness, gastrointestinal discomfort, dizziness and dry mouth in observation group was lower than the control group, and the difference was statistically significant (P<0.05).Conclusion] Xinshu mixetru combined with Sertraline Hydrochloride was much more effective and has less incidentce rate of side effects, and it is worth further clinical research and promotion.