独圣活血片联合双氯芬酸钠治疗急性软组织损伤的疗效观察

目的探讨独圣活血片联合双氯芬酸钠缓释片治疗急性软组织损伤的临床疗效。方法选取2017年3月—2018年3月在威远县人民医院治疗的急性软组织损伤患者74例,根据用药不同分为对照组(37例)和治疗组(37例)。对照组口服双氯芬酸钠缓释片,0.1g/次,2次/d;治疗组在对照组基础上口服独圣活血片,3片/次,3次/d。两组均治疗1周。观察两组患者临床疗效,同时比较治疗前后两组患者症状体征评分和血液流变学指标。结果治疗后,对照组临床有效率为81.08%,显著低于治疗组的97.30%,两组比较差异有统计学意义(P0.05)。治疗后,两组疼痛、压痛、肿胀、功能障碍、瘀斑等症状体征评分均明显降低,同组比较差异具有统计学意义(P0.05);且治疗组上述症状体征各评分明显低于对照组,两组比较差异具有统计学差异(P0.05)。治疗后,两组全血黏度高切、全血黏度低切、血浆黏度、纤维蛋白原水平均显著降低,同组比较差异具有统计学意义(P0.05);且治疗组的血液流变学指标比对照组降低更明显,两组比较差异具有统计学差异(P0.05)。结论独圣活血片联合双氯芬酸钠缓释片治疗急性软组织损伤可有效改善患者临床症状,改善机体血液流变学指标,促进肢体功能恢复。

Clinical observation of Dusheng Huoxue Tablets combined with diclofenac sodium in treatment of acute soft tissue injury

Objective To investigate the clinical effect of Dusheng Huoxue Tablets combined with diclofenac sodium in treatment of acute soft tissue injury. Methods Patients (74 cases) with acute soft tissue injury in the People''s Hospital of Weiyuan from March 2017 to March 2018 were divided into control (37 cases) and treatment (37 cases) groups based on different treatments. Patients in the control group were po administered with Diclofenac Sodium Sustained Release Tablets, 0.1 g/time, twice daily. Patients in the treatment group were po administered with Dusheng Huoxue Tablets on the basis of the control group, 3 tablets/time, three times daily. Patients in two groups were treated for 1 week. After treatment, the clinical efficacy was evaluated, and the symptom and sign scores and hemorheological indexes in two groups before and after treatment were compared. Results After treatment, the clinical efficacy in the control group was 81.08%, which was significantly lower than 97.30% in the treatment group, and there were differences between two groups (P<0.05). After treatment, the pain, tenderness, swelling, dysfunction, and ecchymosis scores in two groups were significantly decreased, and the difference was statistically significant in the same group (P<0.05). And the symptom and sign scores in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P<0.05). After treatment, the whole high viscosity, whole low viscosity, plasma viscosity, and fibrinogen levels in two groups were significantly decreased, and there were differences in the same group (P<0.05). And the hemorheological indexes in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P<0.05). Conclusion Dusheng Huoxue Tablets combined with diclofenac sodium in treatment of acute soft tissue injury can effectively improve the clinical symptoms and hemorheological indexes, and promote the recovery of limb function.