胰高血糖素样肽在骨质疏松症中的研究进展

近年来,胰高血糖素样肽(GLP)在骨质疏松中的作用逐渐被发现。GLP-1除可引起胰岛素分泌增加外,还可促进骨形成、抑制骨吸收。GLP-2除可改善肠道屏障功能,促进营养物质吸收外,还对骨吸收有抑制作用,但对骨形成的影响仍不明确。本文回顾了近年来GLP-1和GLP-2对骨代谢调控作用的相关研究,并重点探讨了GLP-1和GLP-2及其相关药物对骨质疏松症的潜在治疗作用,以期探索骨质疏松的诊疗新思路。

Research progress of glucagon-like peptide in osteoporosis

In recent years, the role of glucagon-like peptide (GLP) in osteoporosis has been discovered. GLP-1 can not only increase insulin secretion, but also promote bone formation and inhibit bone resorption. GLP-2 can not only improve the intestinal barrier and promote the absorption of nutrients, but also inhibit bone resorption. This article reviews the recent studies on the regulation of GLP-1 and GLP-2 on bone metabolism, and focuses on the potential therapeutic effects of GLP-1 and GLP-2 and their related drugs on osteoporosis, with a view to exploring new ideas for the diagnosis and treatment of osteoporosis.