山药化学成分研究

目的研究山药Dioscorea opposita化学成分。方法采用硅胶、Sephadex LH-20、反相ODS等柱色谱方法对化合物进行分离纯化,运用核磁共振波谱等方法鉴定化合物的结构。结果从山药根茎95%乙醇提取物中分离纯化得到14个化合物,包括8个二苯基庚烷类化合物(1～8)和6个含氮化合物(9～14),分别鉴定为5-ethoxy-1,7-diphenylheptan-3-one(1)、5-hydroxy-1,7-bis(4-hydroxyphenyl)-heptan-3-one(2)、1,7-diphenyl-4-hepten-3-one(3)、1,7-bis(4-hydroxyphenyl)-4-hepten-3-one(4)、hannokinol(5)、1-(4-hydroxy-3-methoxyphenyl)-7-(4-hydroxyphen-yl)-3,5-heptanediol(6)、1,7-bis(4-hydroxy-3-methoxyphenyl)-3,5-heptanediol(7)、1,7-bis(4-hydroxyphenyl)-1,5-epoxy-3-hydroxyheptane(8)、trans-N-coumaroyltyramine(9)、trans-N-feruloyltyramine(10)、cis-N-coumaroyltyramine(11)、trans-N-cinnamoyltyramine(12)、pyrrolezanthine-6-ethyl ether(13)、divaricataester A(14)。结论化合物1是新的天然产物,命名为山药庚酮A,化合物3、4、10、12～14为首次从薯蓣科植物中分离得到,化合物2、6、8为首次从山药中分离得到。

Chemical constituents from Dioscorea opposite

Objective To study the chemical constituents of Dioscorea opposita. Methods The constituents were isolated and purified by silica gel, Sephadex LH-20, and ODS column chromatography. Their structures were elucidated by NMR spectra comparison with reference data. Results Fourteen compounds were isolated from 95% ethanol extract of D. opposite. All of them included eight diarylheptanoids (1-8) and six nitrogen compounds (9-14). They were elucidated by spectroscopic data as 5-ethoxy-1,7-diphenylheptan-3-one (1), 5-hydroxy-1,7-bis(4-hydroxyphenyl)-heptan-3-one (2), 1,7-diphenyl-4-hepten-3-one (3), 1,7-bis (4-hydroxyphenyl)-4-hepten-3-one (4), hannokinol (5), 1-(4-hydroxy-3-methoxyphenyl)-7-(4-hydroxyphenyl)-3,5-heptanediol (6), 1,7-bis (4-hydroxy-3-methoxyphenyl)-3,5-heptanediol (7), 1,7-bis(4-hydroxyphenyl)-1,5-epoxy-3-hydroxyheptane (8), trans-N- coumaroyltyramine (9), trans-N-feruloyltyramine (10), cis-N-coumaroyltyramine (11), trans-N-cinnamoyltyramine (12), pyrrolezanthine-6-ethyl ether (13), divaricataester A (14). Conclusion Compounds 1 is a new natural product, named as dioscoheptone A. Compounds 3, 4, 10, 12, 13, and 14 are isolated from the family of dioscoreaceae for the first time. Compounds 2, 6, and 8 are isolated from D. opposita for the first time.