| 甘草类制剂不良反应及其机制研究进展 |
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| 引用本文： | 武媛媛,顾坤,高茜茜,杨非凡,刘传鑫,李遇伯,范思邈. 甘草类制剂不良反应及其机制研究进展[J]. 现代药物与临床, 2018, 41(7): 1363-1368 |
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| 作者姓名： | 武媛媛 顾坤 高茜茜 杨非凡 刘传鑫 李遇伯 范思邈 |
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| 作者单位： | 天津中医药大学 中药学院, 天津 300193,天津中医药大学 中药学院, 天津 300193,天津中医药大学 中药学院, 天津 300193,天津中医药大学 中药学院, 天津 300193,天津中医药大学 中药学院, 天津 300193,天津中医药大学 中药学院, 天津 300193,天津中医药大学 中药学院, 天津 300193 |
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| 基金项目： | 国家自然科学基金资助项目（81573825） |
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| 摘 要： | 近年来中药及其制剂的安全用药备受国内外学者的关注。综述了甘草酸苷注射液、复方甘草口服液、复方甘草片等甘草类制剂不良反应的研究进展，从其引发的内分泌、心血管、神经、生殖、消化、免疫等多个系统的不良反应进行总结阐述，其中主要涉及到的作用机制包括雌激素样作用、糖皮质激素样作用、盐皮质激素样作用等，希望能够指导甘草及其制剂在临床上的合理使用。
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| 关 键 词： | 甘草酸苷制剂 甘草酸苷 药物不良反应 安全用药 |
| 收稿时间： | 2018-01-02 |
Adverse reactions and mechanisms of glycyrrhiza preparation |
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| WU Yuanyuan,GU Kun,GAO Qianqian,YANG Feifan,LIU Chuanxin,LI Yubo and FAN Simiao. Adverse reactions and mechanisms of glycyrrhiza preparation[J]. Drugs & Clinic, 2018, 41(7): 1363-1368 |
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| Authors: | WU Yuanyuan GU Kun GAO Qianqian YANG Feifan LIU Chuanxin LI Yubo FAN Simiao |
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| Affiliation: | College of Pharmacy, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China,College of Pharmacy, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China,College of Pharmacy, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China,College of Pharmacy, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China,College of Pharmacy, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China,College of Pharmacy, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China and College of Pharmacy, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China |
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| Abstract: | In recent years, the safety of traditional Chinese medicine and its preparations have attracted much attention. The research progress of the adverse reactions of glycyrrhizin injection, compound licorice oral liquid, compound licorice tablets and other licorice preparations is reviewed. From the licorice-induced endocrine, cardiovascular, neurological, reproductive, digestive, immune and other systemic adverse reactions is summarized. The main mechanisms involved are estrogen-like effects, glucocorticoid-like effects, and mineralocorticoid-like effects, hope to guide the correct use of licorice and its preparations in clinical practice. |
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| Keywords: | glycyrrhiza preparation glycyrrhizin drug adverse reaction drug safety |
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