2型糖尿病患者糖尿病视网膜病变相关危险因素分析

目的：探讨2型糖尿病( type 2 diabetic mellitus，T2DM)患者糖尿病视网膜病变(diabetic retinopathy，DR)相关危险因素。

方法：回顾性分析2013-01/2017-04收治入院的1 013例T2DM患者病例资料，将DR患者纳入观察组，非DR患者纳入对照组。分析T2DM患者DR相关危险因素。

结果：经调查统计DR发生率为27.74%(281/1 013)。经单因素分析，两组患者性别、年龄、T2DM病程、血压、糖化血红蛋白、高密度脂蛋白胆固醇、肌酐以及24h尿蛋白比较，差异有统计学意义(P<0.05)。经多因素Logistic回归分析，男性、年龄>60岁、T2DM病程>10a以及血压、糖化血红蛋白、高密度脂蛋白胆固醇以及肌酐和24h尿蛋白表达异常均是T2DM患者并发DR的危险因素(P<0.05)。

结论：T2DM患者并发DR风险较高，男性、年龄>60岁、T2DM病程>10a以及血压、糖化血红蛋白、高密度脂蛋白胆固醇以及肌酐和24h尿蛋白的高水平表达均可能是诱发DR的危险因素。

Study on risk factors of diabetic retinopathy in type 2 diabetic patients

AIM:To investigate the risk factors of diabetic retinopathy in type 2 diabetic patients.

METHODS: The data of 1 013 patients with type 2 diabetes mellitus who admitted to hospital from January 2013 to April 2017 were retrospectively analyzed. Diabetic retinopathy patients were included in the observation group, and non diabetic retinopathy patients were included in the control group. Then the risk factors of diabetic retinopathy in type 2 diabetic patients were analyzed.

RESULTS: After investigation, the incidence of DR was 27.74%(281/1013). By univariate analysis, the differences of gender, age, duration of T2DM, blood pressure, HbA1c, HDL-C, creatinine and 24h urine protein between the two groups were statistically significant(P<0.05). Multivariate Logistic regression analysis showed that men, age more than 60 years, T2DM duration of more than 10a, and blood pressure, HbA1c, HDL-C, creatinine, and abnormal expression of 24h urinary protein were risk factors for DR in type 2 diabetes mellitus patients(P<0.05).

CONCLUSION: At present, the risk of DR in patients with type 2 diabetes is also higher. Men, age more than 60 years, T2DM duration of more than 10a, and blood pressure, HbA1c, HDL-C, creatinine, and abnormal expression of 24h urinary protein are risk factors for DR in type 2 diabetes mellitus patients.