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| 玻璃体腔注射康柏西普治疗湿性年龄相关性黄斑变性的早期mfERG变化 | |
| 引用本文： | 黄定国,郑建龙,林国乔,陈伟奇. 玻璃体腔注射康柏西普治疗湿性年龄相关性黄斑变性的早期mfERG变化[J]. 国际眼科杂志, 2018, 18(9): 1692-1695 |
| 作者姓名： | 黄定国 郑建龙 林国乔 陈伟奇 |
| 作者单位： | 中国广东省汕头市,汕头大学·香港中文大学联合汕头国际眼科中心,中国广东省汕头市,汕头大学·香港中文大学联合汕头国际眼科中心,中国广东省汕头市,汕头大学·香港中文大学联合汕头国际眼科中心,中国广东省汕头市,汕头大学·香港中文大学联合汕头国际眼科中心 |
| 基金项目： | 广东省医学科学技术研究基金项目(No.A2016550) |
| 摘 要： | 目的：利用多焦视网膜电图(mfERG)评价玻璃体腔注射康柏西普的湿性年龄相关性黄斑变性(age-related macular degeneration，ARMD)患者视网膜功能的早期变化。 方法：经眼底荧光血管造影确诊为湿性ARMD患者接受玻璃体腔注射康柏西普眼用注射液(0.05mL/0.5mg)，记录注射前及注射后1mo的最佳矫正视力及mfERG各环N1、P1波潜伏期及P1波振幅密度。 结果：共20例20眼患者纳入研究，平均LogMAR视力从注射前0.80±0.48提高到注射后0.65±0.50(P<0.001)，环1平均振幅密度从注射前39.59±16.60nV/deg2提高到注射后的53.81±20.41nV/deg2(P=0.006)，振幅密度的改变与视力的改变呈正相关(r=-0.776，P<0.001)。 结论：对于湿性ARMD患者玻璃体腔注射康柏西普短期内能改善黄斑中心凹的功能。 |
| 关 键 词： | 多焦视网膜电图 康柏西普眼用注射液 湿性年龄相关性黄斑变性 |
| 收稿时间： | 2018-02-02 |
| 修稿时间： | 2018-07-23 |
Early multifocal electroretinography findings after intravitreal Conbercept in the treatment of wet age-related macular degeneration |
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| Ding-Guo Huang,Jian-Long Zheng,Guo-Qiao Lin and Wei-Qi Chen. Early multifocal electroretinography findings after intravitreal Conbercept in the treatment of wet age-related macular degeneration[J]. International Eye Science, 2018, 18(9): 1692-1695 | |
| Authors: | Ding-Guo Huang Jian-Long Zheng Guo-Qiao Lin Wei-Qi Chen |
| Affiliation: | Joint Shantou International Eye Center of Shantou University and the Chinese University of Hong Kong, Shantou 515041, Guangdong Province, China,Joint Shantou International Eye Center of Shantou University and the Chinese University of Hong Kong, Shantou 515041, Guangdong Province, China,Joint Shantou International Eye Center of Shantou University and the Chinese University of Hong Kong, Shantou 515041, Guangdong Province, China and Joint Shantou International Eye Center of Shantou University and the Chinese University of Hong Kong, Shantou 515041, Guangdong Province, China |
| Abstract: | AIM: To evaluate the early changes of retinal function in patients with wet age-related macular degeneration(ARMD)after intravitreal Conbercept treatment by multifocal electroretinography(mfERG). METHODS: Wet ARMD patients diagnosed by fundus fluorescein angiography and received intravitreal injection of Conbercept(0.05mL/0.5mg)were included. Best corrected visual acuity(BCVA), incubation of N1, P1 and amplitude of P1 in mfERG test were recorded before and 1mo after treatment. RESULTS: Twenty patients(20 eyes)were enrolled in total. The mean BCVA was 0.80±0.48 LogMAR at baseline and improved to 0.65±0.50 LogMAR after treatment(P<0.001). Mean P1 amplitude density of the mfERG Ring 1 increased from 39.59±16.60nV/deg2 to 53.81±20.41nV/deg2(P=0.006). The change in visual acuity was positively correlated with the change in P1 amplitude density of Ring 1(r=-0.776, P<0.001). CONCLUSION: Intravitreal conbercept injection can improve the central retinal function of wet ARMD patients in the short term. |
| Keywords: | multifocal electroretinography conbercept wet age-related macular degeneration |
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