放射性125I粒子组织间植入治疗不能手术唾液腺癌患者的生存质量分析

目的 初步评价放射性¹²⁵I粒子组织间植入近距离治疗不能手术唾液腺癌患者的生存质量（quality of life，QOL）及影响因素。方法 选择2013年至2017年间就诊于北京大学口腔医院颌面外科的不能手术唾液腺癌患者23例，行单纯¹²⁵I放射性粒子组织间植入近距离治疗，应用QLQ-C30（V3.0）及QLQ-H&N35中文版生存质量量表，评价患者的生存质量情况，并分析疾病及治疗相关因素对生存质量的影响。结果 23例患者治疗后1年及3年总生存率分别为100%与67%，其治疗前及治疗后生存质量评分平均分为201.48分和199.48分，差异无统计学意义（P>0.05），患者总体生存质量评分及各项功能评分均处于较高水平。疾病及治疗相关因素中，肿瘤发生部位对患者生存质量的影响具有统计学意义（F=9.127，P<0.05），其余因素的影响规律尚需更大样本量的研究。结论 ¹²⁵I放射性粒子组织间植入近距离治疗能较好的保存不能手术唾液腺癌患者的头颈部功能和生存质量。

Study on the influence of 125I seed implantation brachytherapy on QOL of patients with salivary gland malignant tumor

Objective To evaluate the influence of ¹²⁵I seed implantation brachytherapy on QOL of patients with salivary gland malignant tumor which couldn''t be treated by conventional surgery and its influence factors. Methods 23 patients with malignant salivary gland cancer which couldn''t be treated by conventional surgery were selected from Peking University School of Stomatology from 2013 to 2017.The patients were treated by ¹²⁵I seed implantation brachytherapy.EORTC QLQ-C30(V3.0)as well as QLQ-H&N35 QOL scale (Chinese version) were used for the assessment of post-treatment QOL. Results The survival rate of one year and three years after treatment in 23 patients was 100% and 67%, respectively. The score of the quality of life before and after treatment was 201.48 and 199.48, respectively. The difference was not significant after the test (P>0.05). The level of total QOL and function score were relatively high. Among the influence factors, location of tumor significantly influenced QOL(F=9.127,P<0.05). Other factors still needed research based on larger sample. Conclusions ¹²⁵I seed implantaion brachytherapy can better protect the head and neck function and maintain the quality of life of patients with salivary gland malignant tumor.