丝裂霉素C联合顺行泪道引流管置入治疗上泪道阻塞

目的：探讨在顺行泪道引流管置入治疗上泪道阻塞中应用丝裂霉素C的效果。

方法：选取上泪道阻塞患者78例82眼，随机分为观察组(39例42眼)与对照组(39例40眼)，对照组予以顺行泪道引流管置入治疗，观察组在对照组治疗基础上联合丝裂霉素C治疗，对比两组治疗效果。

结果：观察组治疗总有效率81%，显著高于对照组的62%，两组比较差异具有统计学意义(P<0.05)。观察组治疗后的眼表改变评分26.25±1.67分、眼泪SP(P物质)含量256.32±10.07pg/mL低于对照组，泪膜破裂时间8.85±0.89s短于对照组的9.58±0.92s，两组比较差异均具有统计学意义(P<0.05)。

结论：应用丝裂霉素C能够提高顺行泪道引流管置入治疗上泪道阻塞的疗效，改善预后。

Mitomycin C combined with anterograde lacrimal drainage tube implantation for the treatment of upper lacrimal duct obstruction

AIM: To explore the application effect of mitomycin C in lacrimal duct obstruction during anterograde lacrimal drainage tube implantation.

METHODS:Totally 78 cases of lacrimal duct obstruction(82 eyes)were randomly divided into the observation group(39 cases, 42 eyes)and the control group(39 cases, 40 eyes), and the control group was treated with lacrimal drainage tube implantation. The observation group was based on this combined mitomycin C treatment and compared the effect of two groups.

RESULTS: The total effective rate of the observation group was 81%, which was significantly higher than that of the control group(62%), and the difference between the two groups was statistically significant(P<0.05). The eye surface change score(26.25±1.67)and tear SP content(256.32±10.07pg/mL)were lower than that of the control group after treatment. The tear film rupture time(8.85±0.89s)was shorter than that of the control group(9.58±0.92s), and the two groups were statistically significant(P<0.05).

CONCLUSION: Mitomycin C can improve the efficacy of anterograde lacrimal drainage tube implantation for the treatment of lacrimal duct obstruction and improve prognosis.