辛伐他汀治疗原发性肾病综合征高脂血症30例临床观察

目的：观察辛伐他汀治疗原发性肾病综合征高脂血症的临床效果。方法：将原发性肾病综合征患者60例随机分为观察组与对照组，每组30例，对照组给予标准激素治疗，观察组在标准激素治疗的基础上加用辛伐他汀，治疗3周后分别检测两组患者的总胆固醇（TC）、甘油三酯（TG）、高密度脂蛋白胆固醇（HDL—C）、低密度脂蛋白胆固醇（LDL—C）水平及24h尿蛋白定量（24hUPQ）情况。结果：两组治疗后24hUPQ均明显低于治疗前（P〈0．01），观察组治疗后TC、LDL—C水平明显低于治疗前和对照组（P〈0．01）。结论：辛伐他汀治疗原发性肾病综合征高脂血症有较好的临床疗效。

Effect of Simvastatin on hyperlipidemia of primary nephritic syndrome: 30 cases observation

Objective: To observe of Simvastatin on hyperlipidemia of primary nephritic syndrome.Methods: Randomly separated 60 patients with primary nephritic syndrome into observation group and control group,with 30 patients per group.Treated the control group with standard hormone therapy,while treated observation group with Simvastatin and standard hormone.After 3 weeks,tested the status of total cholesterol(TC),triglyceride(TG),high density lipoprotein-cholesterol(HDL-C),low density lipoprotein cholesterol(LDL-C) and 24h urinary protein quantification(24h UPQ) in both two groups.Results: After treatment,the levels of 24 h UPQ declined significantly in both two groups(P<0.01),while the level of TC,and LDL-C in observation group decreased significantly,too(P<0.01).Conclusion: Simvastatin is effective on hyperlipidemia of primary nephritic syndrome.