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Expression of MMP-13 in human temporomandibular joint disc derangement and osteoarthritis |
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| Authors: | Juliano Henrique Perotto Flavio de Alcantara Camejo Andrea Duarte Doetzer Luis Eduardo Almeida Marina Azevedo Márcia Olandoski |
| Affiliation: | 1. School of Health and Biosciences, Pontifícia Universidade Católica do Paraná (PUCPR), Curitiba, Brazil;2. School of Dentistry, Marquette University Milwaukee, Milwaukee, WI, USA |
| Abstract: | Objective: MMP-13 performs digestion of collagen, which is a primary component of the temporomandibular joint (TMJ) articular disc. This study evaluated the expression of MMP-13 in patients with anterior disc displacement with (ADDwR) and without reduction (ADDwoR), and in the presence of TMJ osteoarthrosis. Methods: Thirty-nine human temporomandibular joint disc samples were collected and divided in two ways: ADDwR (21 samples), ADDwoR (10 samples), and a control group (8 samples); and with osteoarthrosis (10 samples) and without osteoarthrosis (29 samples). Immunostaining of the TMJ discs was statistically compared between the groups. Results: There was no statistically significant difference for the area of MMP-13 immunostaining between the control group, ADDwR, and ADDwoR, nor between groups with and without osteoarthrosis. Conclusion: This study suggests MMP-13 is not significantly involved in collagen degradation in human TMJ disc displacement or osteoarthrosis. |
| Keywords: | Temporomandibular disorder disc derangement osteoarthrosis |