Characteristics of patients with coexisting IgA nephropathy and membranous nephropathy |
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| Authors: | Pei Chen Su-Fang Shi Zhen Qu Na Zhao Xin-Fang Xie Ji-Cheng Lv |
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| Institution: | 1. Department of Medicine, Renal Division, Peking University First Hospital, Beijing, China;2. Peking University Institute of Nephrology, Beijing, China;3. Key Laboratory of Renal Disease, Ministry of Health of China, Beijing, China;4. Ministry of Education, Key Laboratory of Chronic Kidney Disease Prevention and Treatment (Peking University), Beijing, China |
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| Abstract: | Background: Coexistence of IgA nephropathy (IgAN) and membranous nephropathy (MN) in the same patient is rare. Few studies have reported the clinical and pathological features of patients with combined IgAN and MN (IgAN–MN).Methods: The clinico-pathological features, levels of galactose-deficient IgA1 (Gd-IgA1) and autoantibodies against M-type transmembrane phospholipase A2 receptor (anti-PLA2R) in sera were compared among IgAN–MN, IgAN, and MN patients.Results: Twenty-six patients with biopsy-proven IgAN–MN were enrolled. The mean age at biopsy was 43.6?±?15.9?years, and 65.4% were male. Proteinuria and estimated glomerular filtration rate (eGFR) levels in patients with IgAN–MN were similar to that of MN patients. Compared with the IgAN patients, IgAN–MN patients showed a higher median proteinuria level (4.3 vs. 1.2?g/day, p?2, p?p?=?.801). Percentage of IgAN–MN patients with detectable serum levels of anti-PLA2R was lower than that of MN patients (38.5% vs. 68.6%, p?=?.011).Conclusions: IgAN–MN patients display similar clinical features to MN patients and milder pathological lesions than IgAN patients. IgAN–MN patients have similar levels of Gd-IgA1 to those of IgAN patients, and a lower proportion of anti-PLA2R than MN patients. |
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| Keywords: | Anti-PLA2R Gd-IgA1 IgA nephropathy IgAN–MN membranous nephropathy |
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