Physiological effects of brominated flame retardants on NC/Nga mice |
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| Authors: | Michitaka Tanaka Akinori Shimada Hirohisa Takano |
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| Institution: | 1. Department of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto University, Kyoto, Japan;2. Laboratory of Pathology, School of Life and Environmental Science, Azabu University, Sagamihara, Japan |
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| Abstract: | Purpose: Brominated flame retardants (BFRs) are used as an additive or reactive components in various materials. Regarding their health concerns, their immunotoxicity have not been clarified yet.Materials and methods: In the current study, we examined the effects of systemic exposure to two types of BFRs, DE71 and DE79, on pathophysiologic traits of murine atopic dermatitis (AD). Male NC/Nga mice were repeatedly injected intraperitoneally with DE71 and DE79 and/or mite allergen (Dermatophagoides pteronyssinus: Dp) into their right ears. Thereafter, clinical scores, macroscopic findings of inflammatory foci, and Ig values in serum were examined.Results: Both DEs significantly aggravated clinical scores induced by mite allergen including skin dryness and edema. Total IgE titer was significantly greater in the Dp?+?DE79 group than in the Dp group.Conclusions: Taken together, exposure to BFRs can exacerbate AD-like skin lesions related to mite allergen in mice. The accentuating effects may be mediated, at least in part, through hyperproduction of IgE. |
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| Keywords: | Brominated flame retardants NC/Nga mice atopic dermatitis clinical scores cytokines |
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