IL-6以及骨代谢生化指标对骨吸收和骨形成的影响

目的 :探讨IL - 6与骨代谢生化指标在老年男性骨质疏松症发病机制中的重要作用。方法 :采用放射免疫分析和生化速率法检测 90例老年男性骨量减少和骨质疏松患者血清白细胞介素 6 (IL - 6 )、骨钙素(BGP)、睾酮 (T)、血清碱性磷酸酶 (SALP)、血清钙 (Ca)的水平 ,同时与青中年和老年健康人比较。结果 :发现老年男性患者骨吸收指标IL - 6水平随病情加重而增高 ,与不同年龄对照组比较有显著性差异 (p <0 .0 1)。骨形成指标BGP、BALP、T表达则不同程度降低 ,均与青中年对照组有明显差异 (p <0 .0 5 ,P <0 .0 1)。结论 :IL - 6及其它骨代谢生化指标代谢异常 ,是导致老年男性骨质疏松症患者骨吸收增加而骨形成减少的重要因素

Influence of IL-6 and Bone Metabolic Markers on Bone Absorption and Osteogenesis

Objective To study the role of Il-6 and bone metabolic markers in the pathogenesis of osteoporosis in aged men. Methods Serum IL-6, bone glaprotein (BGP), testosterone (T), ALP and Ca were measured in 90 old male subjects with RIA and biochemical analytical method. The tested subjects consisted of 40 cases of osteoprosis and 50 cases of decreased bone mass. The values were compared with those in 32 healthy old males and 35 younger subjects as controls. Results Bone absorption marker (IL-6) increased with severity of osteoporosis and the levels were significantly higher than those in controls ( p <0.01). Osteogenesis marker (BGP, SALP and T) decreased by different degrees and were significant lower than those in controls ( p<0.05,p<0 01 ). Conclusion Abnormal serum level of IL-6 and other bone metabolic markers might indicate increased bone absorption and decreased osteogenesis, which were the characteristics of osteoporosis in aged men.