Lipoprotein composition in children and adolescents with type 1 diabetes mellitus |
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Authors: | Bustos Paulina Radojkovic Claudia Ulloa Natalia Muñoz Mirna Martínez Alejandro Calvo Carlos Asenjo Sylvia |
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Affiliation: | Departamento Bioquímica Clinica e Inmunologia, Facultad de Farmacia and Universidad de Concepción, Concepción, Chile. pbustos@udec.cl |
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Abstract: | Atherosclerotic cardiovascular diseases are the major causes of morbidity and mortality in patients with diabetes mellitus. Both quantitative and qualitative abnormalities of lipo-proteins are associated with the development of atherogenesis. In this study, the prevalence of dyslipidemia and the relative levels of glycosylated lipoproteins in 20 children and adolescents with type 1 diabetes mellitus were determined. Lipid profile, apolipoproteins A-I and B, Lp(a) and LpA-I in plasma were assayed. LpB and glycosylated HDL and LDL were evaluated by ELISA. Diabetic patients and controls had normal lipid profiles, but the diabetic group showed significantly higher LpA-I and lower LpA-I:A-II concentrations than controls. The diabetic group showed a significantly higher glycosylation level of HDL than controls and did not show a statistical difference for glycosylated LDL. No significant correlation between glycosylated lipoproteins, glycemia or HbA1c was found. In conclusion, these results suggest that type 1 diabetic patients develop important qualitative lipid abnormalities. |
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