Levels of soluble ICAM-1 in atopic dermatitis A new marker for monitoring the clinical activity? |
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| Authors: | B. Wü thrich,H. Joller-Jemelka,M.K. Kä gi |
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| Affiliation: | Allergy Unit, Department of Dermatology, University Hospital Zurich, Zurich, Switzerland;Section of Clinical Immunology, Department of Internal Medicine, University Hospital Zurich, Zurich, Switzerland |
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| Abstract: | Levels of soluble intercellular adhesion molecule-1 (sICAM-1) were measured in sera from patients with an acute exacerbation of their atopic dermatitis (AD) ( n = 16) on admission to and discharge from our department of dermatology. At admission, the sICAM-1 levels in sera from patients with AD were slightly higher than those of the blood donors ( n = 100) and dropped at discharge significantly ( P = 0.014) after improvement of the skin conditions. Therefore, sICAM-1 may be, together with soluble interleukin-2 receptor (sIL-2), eosinophilic cationic protein (ECP), and CD14, another marker for monitoring AD. |
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| Keywords: | atopic dermatitis intercellular adhesion |
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